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Literature summary extracted from

  • Dengler, V.; McCallum, N.; Kiefer, P.; Christen, P.; Patrignani, A.; Vorholt, J.A.; Berger-Baechi, B.; Senn, M.M.
    Mutation in the C-di-AMP cyclase dacA affects fitness and resistance of methicillin resistant Staphylococcus aureus (2013), PLoS ONE, 8, e73512.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.85 G206S single nucleotide polymorphism identified in in a faster growing but less resistant strain of an isogenic MRSA strain pair that differs in methicillin resistance levels and fitness Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.85 Staphylococcus aureus Q2FW92
-
-
2.7.7.85 Staphylococcus aureus NCTC 8325 Q2FW92
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.7.85 dacA
-
 Staphylococcus aureus
2.7.7.85 SAOUHSC_02407
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.7.7.85 physiological function introduction of single nucleotide polymorphism G206S into an isogenic highly resistant but slower growing strain reduces resistance and increases its growth rate, suggesting a direct connection between the dacA mutation and the phenotypic differences of these strains. The dacA mutation decreases cyclic di-AMP levels resulting in reduced autolysis, increased salt tolerance and a reduction in the basal expression of the cell wall stress stimulon Staphylococcus aureus