Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liu, Y.; Wang, W.; Shui, G.; Huang, X.
    CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway (2014), PLoS Genet., 10, e1004172.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.41 CTP + phosphatidate Drosophila melanogaster
-
 diphosphate + CDP-diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.41 Drosophila melanogaster
-
-
-
2.7.7.41 Drosophila melanogaster P56079
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.41 brain
-
 Drosophila melanogaster
-
2.7.7.41 eye high enzyme content Drosophila melanogaster
-
2.7.7.41 fat body
-
 Drosophila melanogaster
-
2.7.7.41 hindgut
-
 Drosophila melanogaster
-
2.7.7.41 insect tracheal system
-
 Drosophila melanogaster
-
2.7.7.41 malpighian tubule
-
 Drosophila melanogaster
-
2.7.7.41 additional information CdsA is widely expressed in different larval tissues. Broad expression of CdsA Drosophila melanogaster
-
2.7.7.41 muscle
-
 Drosophila melanogaster
-
2.7.7.41 proventriculus
-
 Drosophila melanogaster
-
2.7.7.41 salivary gland
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.41 CTP + phosphatidate
-
 Drosophila melanogaster diphosphate + CDP-diacylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.41 CDP-diacylglycerol synthetase
-
 Drosophila melanogaster
2.7.7.41 CDS
-
 Drosophila melanogaster
2.7.7.41 CdsA
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.7.41 malfunction loss of CdsA function causes significant accumulation of neutral lipids in many tissues along with reduced cell/organ size. These phenotypes can be traced back to reduced phosphatidylinositol levels and, subsequently, low insulin pathway activity. Overexpressing CdsA rescues the fat storage and cell growth phenotypes of insulin pathway mutants. A diacylglycerol-to-phosphatidylethanolamine route mediated by the choline/ethanolamine phosphotransferase Bbc may contribute to the growth of fat cells in silenced CdsA RNAi. CdsA RNAi affects phosphatidylinositol metabolism and insulin pathway activity, strong salivary gland fat storage phenotype of CdsA RNAi. CdsA mutations affect salivary gland fat storage and cell size. But loss of function of CdsA does not affect fat cell lipid storage and growth Drosophila melanogaster
2.7.7.41 physiological function loss of CdsA function causes significant accumulation of neutral lipids in many tissues along with reduced cell/organ size. These phenotypes can be traced back to reduced phosphatidylinositol levels and, subsequently, low insulin pathway activity. Overexpressing CdsA rescues the fat storage and cell growth phenotypes of insulin pathway mutants. CdsA regulates salivary gland fat storage and cell size Drosophila melanogaster
2.7.7.41 physiological function the enzyme diverts phosphatidic acid from triacylglycerol synthesis to phosphatidylinositol synthesis and coordinates cell growth and fat storage. Enzyme CdsA coordinates cell/tissue growth and lipid storage through the insulin pathway. The enzyme is important for the phototransduction pathway. CdsA regulates salivary gland fat storage and cell size Drosophila melanogaster