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Literature summary extracted from

  • Desai, M.; Rangarajan, P.; Donahue, J.L.; Williams, S.P.; Land, E.S.; Mandal, M.K.; Phillippy, B.Q.; Perera, I.Y.; Raboy, V.; Gillaspy, G.E.
    Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants (2014), Plant J., 80, 642-653.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.21 gene vip1, phylogenetic analysis, AtVip1 restores InsP7 synthesis in a Saccharomyces cerevisiae kcs1 mutant Arabidopsis thaliana
2.7.4.21 gene vip2, phylogenetic analysis, AtVip2 restores InsP7 synthesis in a Saccharomyces cerevisiae kcs1 mutant Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
2.7.4.21 D292A site-directed mutagenesis, inactive mutant Arabidopsis thaliana

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.21 Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate Arabidopsis thaliana
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate Arabidopsis thaliana Col-0
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate Arabidopsis thaliana
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate Arabidopsis thaliana Col-0
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate Arabidopsis thaliana
-
 ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate Arabidopsis thaliana Col-0
-
 ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.21 Arabidopsis thaliana
-
-
-
2.7.4.21 Arabidopsis thaliana Col-0
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.21 leaf
-
 Arabidopsis thaliana
-
2.7.4.21 root
-
 Arabidopsis thaliana
-
2.7.4.21 seed
-
 Arabidopsis thaliana
-
2.7.4.21 seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1,3-bis(diphosphate) 2,4,5,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1,3-bis(diphosphate) 2,4,5,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1-triphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1-triphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Arabidopsis thaliana ADP + 1D-myo-inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.4.21 More Vip1 domain organization Arabidopsis thaliana
2.7.4.21 More Vip2 domain organization Arabidopsis thaliana

Synonyms

EC Number Synonyms Comment Organism
2.7.4.21 AtVip1
-
 Arabidopsis thaliana
2.7.4.21 AtVip2
-
 Arabidopsis thaliana
2.7.4.21 InsP6 kinase
-
 Arabidopsis thaliana
2.7.4.21 IP6K
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.4.21 ATP
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.7.4.21 additional information a small amount of InsP7 and InsP8 is accumulated in seeds of higher plants. Residue D292 of AtVIP1 is critical for activity of the kinase domain. The kinase domains alone does not show InsP7 synthesis activity to same levels as the intact AtVIP1 Arabidopsis thaliana
2.7.4.21 additional information a small amount of InsP7 and InsP8 is accumulated in seeds of higher plants. The kinase domains alone does not show InsP7 synthesis activity to same levels as the intact AtVIP2 Arabidopsis thaliana
2.7.4.21 physiological function isozymes AtVip1 and AtVip2 are differentially expressed in plant tissues, suggesting nonredundant or non-overlapping functions in plants. Both AtVip1 and AtVip2 encode proteins capable of restoring InsP7 synthesis in Saccharomyces cerevisiae mutants, AtVip1 and AtVip2 can function as bonafide InsP6 kinases. The plant paralogues of the yeast Vip genes can catalyze the synthesis of InsP7 and correct the phenotypic consequences of a yeast vip1 null mutation Arabidopsis thaliana
2.7.4.21 physiological function isozymes AtVip1 and AtVip2 are differentially expressed in plant tissues, suggesting nonredundant or non-overlapping functions in plants. Both AtVip1 and AtVip2 encode proteins capable of restoring InsP7 synthesis in yeast mutants, thus AtVip1 and AtVip2 can function as bonafide InsP6 kinases. The plant paralogues of the Saccharomyces cerevisiae Vip genes can catalyze the synthesis of InsP7 and correct the phenotypic consequences of a yeast vip1 null mutation Arabidopsis thaliana