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Literature summary extracted from

  • Smithen, D.A.; Forget, S.M.; McCormick, N.E.; Syvitski, R.T.; Jakeman, D.L.
    Polyphosphate-containing bisubstrate analogues as inhibitors of a bacterial cell wall thymidylyltransferase (2015), Org. Biomol. Chem., 13, 3347-3350.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.24 deoxythymidine 5'-tetraphosphate bisubstrate inhibitor with increased length of polyphosphate linker, competitve inhibition Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.24 Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.24 dTTP + alpha-D-glucose 1-phosphate
-
 Streptococcus pneumoniae diphosphate + dTDP-alpha-D-glucose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.24 Cps2L
-
 Streptococcus pneumoniae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.24 0.085
-
 deoxythymidine 5'-tetraphosphate pH 7.5, temperature not specified in the publication Streptococcus pneumoniae