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Literature summary extracted from

  • Wang, C.; Zhou, J.; Jang, H.J.; Yoon, S.H.; Kim, J.Y.; Lee, S.G.; Choi, E.S.; Kim, S.W.
    Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli (2013), Metab. Eng., 18, 53-59.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.68 expressed in Escherichia coli SN-IRv cells Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.68 V107G inactive Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.68 0.0045
-
 isopentenyl diphosphate pH and temperature not specified in the publication Mycobacterium tuberculosis
2.5.1.68 0.0078
-
 geranyl diphosphate pH and temperature not specified in the publication Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.68 Mg2+ dependent on Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate Mycobacterium tuberculosis
-
 diphosphate + (2Z,6E)-farnesyl diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.68 Mycobacterium tuberculosis P9WFF5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate
-
 Mycobacterium tuberculosis diphosphate + (2Z,6E)-farnesyl diphosphate
-
 ?
2.5.1.68 additional information the enzyme cannot use dimethylallyl diphosphate as a substrate Mycobacterium tuberculosis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.68 Rv1086
-
 Mycobacterium tuberculosis
2.5.1.68 Z,E-FPP synthase
-
 Mycobacterium tuberculosis