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Literature summary extracted from

  • Ohya, N.; Ichijo, T.; Sato, H.; Nakamura, T.; Yokota, S.; Sagami, H.; Nagaki, M.
    Specificity of geranylgeranyl diphosphate synthase for homoallylic substrate analogs (2015), J. Mol. Catal. B, 120, 179-182.
No PubMed abstract available

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.29 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate Homo sapiens
-
 diphosphate + geranylgeranyl diphosphate
-
 ?
2.5.1.29 additional information Homo sapiens enzyme geranylgeranyl diphosphate synthase catalyzes the sequential condensation of isopentenyl diphosphates with the allylic substrates dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), or both to produce geranylgeranyl diphosphate (GGPP) ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.29 Homo sapiens O95749
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
-
 Homo sapiens diphosphate + geranylgeranyl diphosphate
-
 ?
2.5.1.29 geranyl diphosphate + 3-desmethylisopentenyl diphosphate i.e. but-3-enyl diphosphate Homo sapiens diphosphate + 3-desmethylfarnesyl diphosphate
-
 ?
2.5.1.29 geranyl diphosphate + 3-ethylbut-3-enyl diphosphate
-
 Homo sapiens diphosphate + 3-ethylfarnesyl diphosphate
-
 ?
2.5.1.29 geranyl diphosphate + 3-propylbut-3-enyl diphosphate
-
 Homo sapiens diphosphate + 3-propylfarnesyl diphosphate
-
 ?
2.5.1.29 additional information enzyme geranylgeranyl diphosphate synthase catalyzes the sequential condensation of isopentenyl diphosphates with the allylic substrates dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), or both to produce geranylgeranyl diphosphate (GGPP) Homo sapiens ?
-
 ?
2.5.1.29 additional information enzyme substrate specificity in reactions using 3-alkyl analogues of isopentenyl diphosphate as substrate, overview. No activity with 3-butylbut-3-enyl diphosphate Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.29 GGPPase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.29 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.29 7.4
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
2.5.1.29 additional information enzyme-substrate docking using the crystal structure of human GGPPase, PDB ID 2Q80PDB Homo sapiens