Literature summary extracted from

Kawatkar, S.P.; Keating, T.A.; Olivier, N.B.; Breen, J.N.; Green, O.M.; Guler, S.Y.; Hentemann, M.F.; Loch, J.T.; McKenzie, A.R.; Newman, J.V.; Otterson, L.G.; Martinez-Botella, G.
Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region (2014), J. Med. Chem., 57, 4584-4597.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.4.9	2-(3-chlorophenoxy)-3-methoxy-4-[(1S)-1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl]benzoic acid	2 g/ml MIC against methicillin-resistant Staphylococcus aureus. The compound exhibits a striking inverted chiral preference for binding relative to earlier compounds and also has improved physical properties and pharmacokinetics	Staphylococcus aureus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.4.9	Staphylococcus aureus	-	-	-

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.7.4.9	0.000003	-	temperature not specified in the publication, pH not specified in the publication	Staphylococcus aureus	2-(3-chlorophenoxy)-3-methoxy-4-[(1S)-1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl]benzoic acid

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Release 2023.1 (January 2023)