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Literature summary extracted from

  • Capasso, C.; Supuran, C.T.
    Sulfa and trimethoprim-like drugs - antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors (2014), J. Enzyme Inhib. Med. Chem., 29, 379-387.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 sulfacetamide competitive inhibitor Bacillus anthracis
2.5.1.15 sulfacetamide competitive inhibitor Yersinia pestis
2.5.1.15 sulfamethoxazole competitive inhibitor Bacillus anthracis
2.5.1.15 sulfamethoxazole competitive inhibitor Yersinia pestis
2.5.1.15 sulfathiazole competitive inhibitor Bacillus anthracis
2.5.1.15 sulfathiazole competitive inhibitor Yersinia pestis
2.5.1.15 sulfisomidine competitive inhibitor Bacillus anthracis
2.5.1.15 sulfisomidine competitive inhibitor Yersinia pestis
2.5.1.15 sulfonamide competitive inhibitor Bacillus anthracis
2.5.1.15 sulfonamide competitive inhibitor Yersinia pestis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Yersinia pestis
-
 diphosphate + 7,8-dihydropteroate
-
 ?
2.5.1.15 (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Bacillus anthracis
-
 diphosphate + 7,8-dihydropteroate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Bacillus anthracis
-
-
-
2.5.1.15 Yersinia pestis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Yersinia pestis diphosphate + 7,8-dihydropteroate
-
 ?
2.5.1.15 (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Bacillus anthracis diphosphate + 7,8-dihydropteroate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.15 DHP synthase
-
 Yersinia pestis
2.5.1.15 DHP synthase
-
 Bacillus anthracis
2.5.1.15 DHPS
-
 Yersinia pestis
2.5.1.15 DHPS
-
 Bacillus anthracis