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Literature summary extracted from

  • Li, L.; Homan, K.T.; Vishnivetskiy, S.A.; Manglik, A.; Tesmer, J.J.; Gurevich, V.V.; Gurevich, E.V.
    G protein-coupled receptor kinases of the GRK4 protein subfamily phosphorylate inactive G protein-coupled receptors (GPCRs) (2015), J. Biol. Chem., 290, 10775-10790.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.16 expressed in High-5 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.16 ATP + [G-protein-coupled receptor] Homo sapiens GRK5 effectively phosphorylates inactive forms of several G-protein-coupled receptors, including serotonin 5-HT2C, beta2-adrenergic and M2 muscarinic receptors and rhodopsin ADP + [G-protein-coupled receptor]phosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.16 Homo sapiens P34947
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-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.16 Ni-NTA column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.16 ATP + [G-protein-coupled receptor] GRK5 effectively phosphorylates inactive forms of several G-protein-coupled receptors, including serotonin 5-HT2C, beta2-adrenergic and M2 muscarinic receptors and rhodopsin Homo sapiens ADP + [G-protein-coupled receptor]phosphate
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.16 G protein-coupled receptor kinase 5
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 Homo sapiens
2.7.11.16 GRK5
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 Homo sapiens