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Literature summary extracted from

  • Castro-Fernandez, V.; Bravo-Moraga, F.; Ramirez-Sarmiento, C.A.; Guixe, V.
    Emergence of pyridoxal phosphorylation through a promiscuous ancestor during the evolution of hydroxymethyl pyrimidine kinases (2014), FEBS Lett., 588, 3068-3073.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.35 Escherichia coli P40191
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-
2.7.1.49 Salmonella enterica subsp. enterica serovar Typhimurium P55882
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-
2.7.1.49 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 P55882
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-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.35 PdxK
-
 Escherichia coli
2.7.1.49 ThiD
-
 Salmonella enterica subsp. enterica serovar Typhimurium

General Information

EC Number General Information Comment Organism
2.7.1.35 additional information experimental resurrection of the last common ancestor of the hydroxymethyl pyrimidine kinase group based on comparison of hydroxymethyl pyrimidine and pyridoxal kinases. Probably the last common ancestor was not able to use pyridoxal under physiological conditions. The pyridoxal kinase activity present in the current bifunctional enzymes must have appeared in a convergent event independently of the pyridoxal kinase activity of pdxY and pdxK genes. Substrate pyridoxal is 8-times less preferred than the phosphorylation of hydroxymethyl pyrimidine by the last ancestor Escherichia coli
2.7.1.49 additional information experimental resurrection of the last common ancestor of the hydroxymethyl pyrimidine kinase group based on comparison of hydroxymethyl pyrimidine and pyridoxal kinases. Probably the last common ancestor was not able to use pyridoxal under physiological conditions. The pyridoxal kinase activity present in the current bifunctional enzymes must have appeared in a convergent event independently of the pyridoxal kinase activity of pdxY and pdxK genes. Substrate pyridoxal is 8-times less preferred than the phosphorylation of hydroxymethyl pyrimidine by the last ancestor Salmonella enterica subsp. enterica serovar Typhimurium