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Literature summary extracted from

  • Leung, C.Y.; Langille, A.M.; Mancuso, J.; Tsantrizos, Y.S.
    Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase - parallel synthesis of analogs via a trimethylsilyl ylidene intermediate (2013), Bioorg. Med. Chem., 21, 2229-2240.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.10 (((2-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid about 75% inhibition at 0.01 mM Homo sapiens
2.5.1.10 (((5-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid about 10% inhibition at 0.01 mM Homo sapiens
2.5.1.10 (((6-(4-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid about 85% inhibition at 0.01 mM Homo sapiens
2.5.1.10 (((6-(naphthalen-2-yl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)diphosphonic acid about 87% inhibition at 0.01 mM Homo sapiens
2.5.1.10 (6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylenebisphosphonic acid about 61% inhibition at 0.01 mM Homo sapiens
2.5.1.10 (thieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid about 78% inhibition at 0.01 mM Homo sapiens
2.5.1.10 [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid) about 90% inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate Homo sapiens
-
 diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.10 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate
-
 Homo sapiens diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.10 farnesyl pyrophosphate synthase
-
 Homo sapiens
2.5.1.10 FPPS
-
 Homo sapiens