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Literature summary extracted from

  • Lanz, N.D.; Lee, K.H.; Horstmann, A.K.; Pandelia, M.E.; Cicchillo, R.M.; Krebs, C.; Booker, S.J.
    Characterization of Lipoyl Synthase from Mycobacterium tuberculosis (2016), Biochemistry, 55, 1372-1383.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.1.8 protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] ferredoxin Mycobacterium tuberculosis
-
 protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] ferredoxin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.8 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.1.8 Ni-NTA resin chromatography and Sephacryl 200 gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.8 H protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] dithionite
-
 Mycobacterium tuberculosis H protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] dithionite
-
 ?
2.8.1.8 H protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] flavodoxin
-
 Mycobacterium tuberculosis H protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] flavodoxin
-
 ?
2.8.1.8 protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] ferredoxin
-
 Mycobacterium tuberculosis protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] ferredoxin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.1.8 LipA
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.1.8 4Fe-4S-center the enzyme LipA harbors two [4Fe-4S] clusters that are essential for its activity Mycobacterium tuberculosis