EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.5.1.10 | in complex with isopentenyl diphosphate and inhibitors, hanging drop vapor diffusion method, using 15-25% (w/v) PEG 3350, 0.1-0.2 M calcium acetate, 0.1 M MES sodium salt pH 6.5 | Leishmania major |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.10 | 1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridinium | - |
Leishmania major | |
2.5.1.10 | 3-butyl-1-(2,2-diphosphonoethyl)pyridinium | - |
Leishmania major | |
2.5.1.10 | 3-fluoro-1-(2-hydroxy-2,2-diphosphonoethyl)-pyridinium | - |
Leishmania major | |
2.5.1.10 | zoledronate | - |
Leishmania major |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.10 | Mg2+ | contains Mg2+ | Leishmania major |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.10 | geranyl diphosphate + isopentenyl diphosphate | Leishmania major | - |
diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.10 | Leishmania major | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.5.1.10 | HisTrap Ni2+-chelate column chromatography | Leishmania major |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.10 | geranyl diphosphate + isopentenyl diphosphate | - |
Leishmania major | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.5.1.10 | homodimer | - |
Leishmania major |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.10 | farnesyl pyrophosphate synthase | - |
Leishmania major |
2.5.1.10 | FPPS | - |
Leishmania major |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.10 | 0.000001 | - |
1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridinium | pH and temperature not specified in the publication | Leishmania major | |
2.5.1.10 | 0.000011 | - |
zoledronate | pH and temperature not specified in the publication | Leishmania major | |
2.5.1.10 | 0.00005 | - |
3-fluoro-1-(2-hydroxy-2,2-diphosphonoethyl)-pyridinium | pH and temperature not specified in the publication | Leishmania major |