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Literature summary extracted from

  • Rzad, K.; Gabriel, I.
    Characterization of two aminotransferases from Candida albicans (2015), Acta Biochim. Pol., 62, 903-912.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.39 expression in Escherichia coli Candida albicans
2.6.1.57 expression in Escherichia coli Candida albicans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.39 0.02
-
 L-2-aminoadipate pH 7.0, 22°C Candida albicans
2.6.1.39 0.1
-
 2-oxoadipate pH 7.0, 22°C Candida albicans
2.6.1.57 0.01
-
 phenylpyruvate pH 7.0, 22°C Candida albicans
2.6.1.57 0.03
-
 4-hydroxyphenylpyruvate pH 7.0, 22°C Candida albicans
2.6.1.57 0.05
-
 L-phenylalanine pH 7.0, 22°C Candida albicans
2.6.1.57 0.1
-
 L-tyrosine pH 7.0, 22°C Candida albicans
2.6.1.57 0.1
-
 2-oxoadipate pH 7.0, 22°C Candida albicans
2.6.1.57 0.24
-
 L-phenylalanine pH 7.0, 22°C Candida albicans
2.6.1.57 0.46
-
 L-tyrosine pH 7.0, 22°C Candida albicans
2.6.1.57 1.07
-
 L-tryptophan pH 7.0, 22°C Candida albicans
2.6.1.57 1.45
-
 L-tryptophan pH 7.0, 22°C Candida albicans
2.6.1.57 3.59
-
 pyruvate pH 7.0, 22°C Candida albicans
2.6.1.57 5.19
-
 2-oxoglutarate pH 7.0, 22°C Candida albicans
2.6.1.57 7.04
-
 glyoxylate pH 7.0, 22°C Candida albicans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.39 55000
-
-
 Candida albicans
2.6.1.39 56400
-
-
 Candida albicans
2.6.1.39 69500
-
 PAGE Candida albicans
2.6.1.39 73500
-
 gel filtration Candida albicans
2.6.1.57 55000
-
-
 Candida albicans
2.6.1.57 55000
-
 PAGE Candida albicans
2.6.1.57 56400
-
-
 Candida albicans
2.6.1.57 63000
-
 gel filtration Candida albicans
2.6.1.57 69500
-
 PAGE Candida albicans
2.6.1.57 73500
-
 gel filtration Candida albicans
2.6.1.57 97000
-
 PAGE Candida albicans

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.39 Candida albicans A0A1D8PG20
-
-
2.6.1.39 Candida albicans ATCC MYA-2876 A0A1D8PG20
-
-
2.6.1.57 Candida albicans
-
-
-
2.6.1.57 Candida albicans A0A1D8PG20
-
-
2.6.1.57 Candida albicans ATCC MYA-2876
-
-
-
2.6.1.57 Candida albicans ATCC MYA-2876 A0A1D8PG20
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.39 2-oxoadipate + L-glutamate
-
 Candida albicans L-2-aminoadipate + 2-oxoglutarate
-
 r
2.6.1.39 L-2-aminoadipate + 2-oxoglutarate
-
 Candida albicans 2-oxoadipate + L-glutamate
-
 r
2.6.1.39 additional information enzyme displays aromatic and alpha-aminoadipate aminotransferase activity, ECs 2.4.1.39 and 2.4.1.57 Candida albicans ?
-
 ?
2.6.1.57 4-hydroxyphenylpyruvate + L-glutamate
-
 Candida albicans L-tyrosine + 2-oxoglutarate
-
 ?
2.6.1.57 L-phenylalanine + 2-oxoadipate
-
 Candida albicans phenylpyruvate + L-2-aminoadipate
-
 r
2.6.1.57 L-phenylalanine + 2-oxoglutarate
-
 Candida albicans phenylpyruvate + L-glutamate
-
 ?
2.6.1.57 L-phenylalanine + 2-oxoglutarate
-
 Candida albicans phenylpyruvate + L-glutamate
-
 r
2.6.1.57 L-phenylalanine + 2-oxoglutarate
-
 Candida albicans ATCC MYA-2876 phenylpyruvate + L-glutamate
-
 ?
2.6.1.57 L-phenylalanine + 2-oxoglutarate
-
 Candida albicans ATCC MYA-2876 phenylpyruvate + L-glutamate
-
 r
2.6.1.57 L-phenylalanine + glyoxylate
-
 Candida albicans phenylpyruvate + glycine
-
 r
2.6.1.57 L-phenylalanine + glyoxylate
-
 Candida albicans ATCC MYA-2876 phenylpyruvate + glycine
-
 r
2.6.1.57 L-phenylalanine + pyruvate
-
 Candida albicans phenylpyruvate + L-alanine
-
 r
2.6.1.57 L-phenylalanine + pyruvate
-
 Candida albicans ATCC MYA-2876 phenylpyruvate + L-alanine
-
 r
2.6.1.57 L-tryptophan + 2-oxoglutarate
-
 Candida albicans 3-indole-2-oxopropanoate + L-glutamate
-
 ?
2.6.1.57 L-tryptophan + 2-oxoglutarate
-
 Candida albicans 3-indole-2-oxopropanoate + L-glutamate
-
 r
2.6.1.57 L-tryptophan + 2-oxoglutarate
-
 Candida albicans ATCC MYA-2876 3-indole-2-oxopropanoate + L-glutamate
-
 ?
2.6.1.57 L-tryptophan + 2-oxoglutarate
-
 Candida albicans ATCC MYA-2876 3-indole-2-oxopropanoate + L-glutamate
-
 r
2.6.1.57 L-tyrosine + 2-oxoglutarate
-
 Candida albicans 4-hydroxyphenylpyruvate + L-glutamate
-
 ?
2.6.1.57 L-tyrosine + 2-oxoglutarate
-
 Candida albicans 4-hydroxyphenylpyruvate + L-glutamate
-
 r
2.6.1.57 L-tyrosine + 2-oxoglutarate
-
 Candida albicans ATCC MYA-2876 4-hydroxyphenylpyruvate + L-glutamate
-
 ?
2.6.1.57 additional information enzyme displays aromatic and alpha-aminoadipate aminotransferase activity, ECs 2.4.1.39 and 2.4.1.57 Candida albicans ?
-
 ?
2.6.1.57 additional information enzyme displays aromatic and alpha-aminoadipate aminotransferase activity, ECs 2.4.1.39 and 2.4.1.57 Candida albicans ATCC MYA-2876 ?
-
 ?
2.6.1.57 phenylpyruvate + L-glutamate
-
 Candida albicans L-phenylalanine + 2-oxoglutarate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.6.1.39 monomer 1 * 55000, SDS-PAGE, 1 * 56400, calculated Candida albicans
2.6.1.57 dimer and monomer, 2 * 55000, SDS-PAGE Candida albicans
2.6.1.57 monomer 1 * 55000, SDS-PAGE, 1 * 56400, calculated Candida albicans
2.6.1.57 monomer and some dimer, 1 * 55000, SDS-PAGE Candida albicans

Synonyms

EC Number Synonyms Comment Organism
2.6.1.39 Aro8
-
 Candida albicans
2.6.1.57 Aro8
-
 Candida albicans
2.6.1.57 Yer152
-
 Candida albicans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.39 8
-
-
 Candida albicans
2.6.1.57 8
-
-
 Candida albicans