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Literature summary extracted from

  • Zabka, T.S.; Singh, J.; Dhawan, P.; Liederer, B.M.; Oeh, J.; Kauss, M.A.; Xiao, Y.; Zak, M.; Lin, T.; McCray, B.; La, N.; Nguyen, T.; Beyer, J.; Farman, C.; Uppal, H.; Dragovich, P.S.; OBrien, T.; Sampath, D.; Misner, D.L.
    Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase (2015), Toxicol. Sci., 144, 163-172.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 APO866 formerly FK866 Homo sapiens
2.4.2.12 APO866 formerly FK866 Rattus norvegicus
2.4.2.12 GMX-1778 formerly CHS-828 Homo sapiens
2.4.2.12 GMX-1778 formerly CHS-828 Rattus norvegicus
2.4.2.12 GNE-617
-
 Homo sapiens
2.4.2.12 GNE-618
-
 Homo sapiens
2.4.2.12 GNE-643
-
 Homo sapiens
2.4.2.12 GNE-875
-
 Homo sapiens
2.4.2.12 N-(4-[[3-(trifluoromethyl)phenyl]sulfonyl]benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
-
 Homo sapiens
2.4.2.12 N-(4-[[3-(trifluoromethyl)phenyl]sulfonyl]benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
-
 Rattus norvegicus
2.4.2.12 N-[(5-[[3-(trifluoromethyl)phenyl]sulfonyl]pyridin-2-yl)methyl]furo[2,3-c]pyridine-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[(5-[[3-(trifluoromethyl)phenyl]sulfonyl]pyridin-2-yl)methyl]furo[2,3-c]pyridine-2-carboxamide
-
 Rattus norvegicus
2.4.2.12 N-[4-[(3,5-difluorophenyl)sulfonyl]benzyl]imidazo[1,2-a]pyridine-6-carboxamide
-
 Homo sapiens
2.4.2.12 N-[4-[(3,5-difluorophenyl)sulfonyl]benzyl]imidazo[1,2-a]pyridine-6-carboxamide
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Rattus norvegicus
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens P43490
-
-
2.4.2.12 Rattus norvegicus Q80Z29
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 A-2780 cell
-
 Homo sapiens
-
2.4.2.12 HCT-116 cell
-
 Homo sapiens
-
2.4.2.12 HT-1080 cell
-
 Homo sapiens
-
2.4.2.12 PC-3 cell
-
 Homo sapiens
-
2.4.2.12 retinal pigment epithelium cell
-
 Rattus norvegicus
-
2.4.2.12 retinal pigment epithelium cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Rattus norvegicus nicotinamide D-ribonucleotide + diphosphate
-
 ?
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 Nampt
-
 Rattus norvegicus
2.4.2.12 Nampt
-
 Homo sapiens