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Literature summary extracted from

  • Keinanen, T.; Hyvonen, T.; Vepsalainen, J.; Alhonen, L.; Khomutov, A.; Janne, J.
    Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme (2014), Russ. J. Bioorg. Chem., 40, 155-161.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.57 additional information conjugates of symmetrical polyamines spermine , 1,12-diamino-4,9-diazadodecane and of nor-spermidine, 1,7-diamino-4-azaheptane, with coenzyme A, mimicking intermediate the coenzyme-substrate complex, are synthesized to inhibit the enzyme, overview Homo sapiens
2.3.1.57 O-(11-amino-3,8-diaza-1-undecyl)oxime S-(2-oxopropyl)-CoA
-
 Homo sapiens
2.3.1.57 O-(11-amino-3,8-diaza-1-undecyl)oxime S-(2-oxopropyl)-D-pantetheine
-
 Homo sapiens
2.3.1.57 O-(6-amino-3-aza-1-hexyl)oxime S-(2-oxopropyl)-CoA
-
 Homo sapiens
2.3.1.57 O-(6-amino-3-aza-1-hexyl)oxime S-(2-oxopropyl)-D-pantetheine
-
 Homo sapiens
2.3.1.57 O-(7-amino-3-aza-1-heptyl)oxime S-(2-oxopropyl)-CoA
-
 Homo sapiens
2.3.1.57 O-(7-amino-3-aza-1-heptyl)oxime S-(2-oxopropyl)-D-pantetheine
-
 Homo sapiens
2.3.1.57 O-(7-amino-4-aza-1-heptyl)oxime S-(2-oxopropyl)-CoA
-
 Homo sapiens
2.3.1.57 O-(7-amino-4-aza-1-heptyl)oxime S-(2-oxopropyl)-D-pantetheine
-
 Homo sapiens
2.3.1.57 S-(2-oxopropyl)-CoA
-
 Homo sapiens
2.3.1.57 S-(2-oxopropyl)-D-pantetheine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 3 acetyl-CoA + 2 spermine Homo sapiens
-
 3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
-
 ?
2.3.1.57 3 acetyl-CoA + spermidine Homo sapiens
-
 3 CoA + N1,N4,N8-triacetylspermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Homo sapiens P21673
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 3 acetyl-CoA + 2 spermine
-
 Homo sapiens 3 CoA + N1-acetylspermine + N1,N12-diacetylspermine
-
 ?
2.3.1.57 3 acetyl-CoA + spermidine
-
 Homo sapiens 3 CoA + N1,N4,N8-triacetylspermidine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.57 spermidine/spermine-N 1-acetyltransferase
-
 Homo sapiens
2.3.1.57 SSAT
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.57 acetyl-CoA
-
 Homo sapiens