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Literature summary extracted from

  • Mueller, R.; Jenny, A.; Stanley, P.
    The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila (2013), PLoS ONE, 8, e62835.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.255 Drosophila melanogaster Q9VQB7
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2.4.1.255 Homo sapiens Q5NDL2
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.255 EGF domain-specific O-linked N-acetylglucosamine transferase
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 Drosophila melanogaster
2.4.1.255 EGF domain-specific O-linked N-acetylglucosamine transferase
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 Homo sapiens
2.4.1.255 EOGT
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 Drosophila melanogaster
2.4.1.255 EOGT
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 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.1.255 physiological function Eogt may regulate protein functions by O-GlcNAc modification of their EGF repeats, and cellular metabolism by affecting pyrimidine synthesis and catabolism. Eogt knock-down in the wing leads to metabolic and signaling perturbations that increase cytosolic uracil levels, thereby causing wing blister formation Drosophila melanogaster
2.4.1.255 physiological function transfection of human EOGT cDNA causes O-GlcNAcylation of Drosphila N, Dl and Ser EGF repeats. EOGT requires a conserved DXD motif for optimal activity, and it is primarily responsible for the transfer of OGlcNAc to high molecular weight proteins, including Dp, in Drosophila larvae. In vivo, the human EOGT cDNA fully rescues homozygotes of a P-element excision mutation of EOGT Homo sapiens