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Literature summary extracted from

  • Wang, L.; Schmidl, S.R.; Stuelke, J.
    Mycoplasma pneumoniae thymidine phosphorylase (2014), Nucleosides Nucleotides Nucleic Acids, 33, 296-304.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 5-fluorocytosine
-
 Mycoplasma pneumoniae
2.4.2.4 5-fluorodeoxyuridine
-
 Mycoplasma pneumoniae
2.4.2.4 5-fluorouracil
-
 Mycoplasma pneumoniae
2.4.2.4 5-iododeoxyuridine
-
 Mycoplasma pneumoniae
2.4.2.4 6-thioguanine
-
 Mycoplasma pneumoniae
2.4.2.4 acyclovir
-
 Mycoplasma pneumoniae
2.4.2.4 Cidofovir
-
 Mycoplasma pneumoniae
2.4.2.4 dipyridamole
-
 Mycoplasma pneumoniae
2.4.2.4 gancyclovir
-
 Mycoplasma pneumoniae
2.4.2.4 gemcitabine
-
 Mycoplasma pneumoniae
2.4.2.4 additional information not inhibited by pyrimethamine, fludarabine phosphate, lamivudine, adefovir depivoxil, 5-azacytidine, azathioprine, arabinosyl adenine, zalcitabine, caffeine, 7-(2,3-dihydroxypropyl)theophylline, theophylline, allopurinol, 6-mercaptopurine, and valacyclovir Mycoplasma pneumoniae
2.4.2.4 mycophenolate mofetil
-
 Mycoplasma pneumoniae
2.4.2.4 pentoxifylline
-
 Mycoplasma pneumoniae
2.4.2.4 ribavirin
-
 Mycoplasma pneumoniae
2.4.2.4 stavudine
-
 Mycoplasma pneumoniae
2.4.2.4 trifluorothymidine
-
 Mycoplasma pneumoniae
2.4.2.4 zidovudine
-
 Mycoplasma pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 thymidine + phosphate Mycoplasma pneumoniae
-
 thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate Mycoplasma pneumoniae M129
-
 thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Mycoplasma pneumoniae P75052
-
-
2.4.2.4 Mycoplasma pneumoniae M129 P75052
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 thymidine + phosphate
-
 Mycoplasma pneumoniae thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate
-
 Mycoplasma pneumoniae M129 thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.4 deoA
-
 Mycoplasma pneumoniae

General Information

EC Number General Information Comment Organism
2.4.2.4 physiological function thymidine phosphorylase is not essential for Mycoplasma pneumoniae survival Mycoplasma pneumoniae