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Literature summary extracted from

  • Sanders, A.N.; Wright, L.F.; Pavelka, M.S.
    Genetic characterization of mycobacterial L,D-transpeptidases (2014), Microbiology, 160, 1795-1806.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.12 additional information mutant DELTAldtC is hypersusceptible to imipenem Mycolicibacterium smegmatis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.12 Imipenem
-
 Mycobacterium tuberculosis
2.3.2.12 Imipenem
-
 Mycolicibacterium smegmatis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.12 27600
-
 x * 27600, LtdA, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 28500
-
 x * 28500, LtdA, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 29800
-
 x * 29800, LtdD, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 38100
-
 x * 38100, LtdE, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 40200
-
 x * 40200, LtdE, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 44000
-
 x * 44000, LtdB, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 44900
-
 x * 44900, LtdB, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 46200
-
 x * 46200, LtdF, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 49600
-
 x * 49600, LtdC, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 49700
-
 x * 49700, LtdC, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 49700
-
 x * 49700, LtdG, calculated from amino acid sequence Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2 Mycolicibacterium smegmatis
-
 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2 Mycobacterium tuberculosis
-
 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2 Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2 Mycobacterium tuberculosis H37Rv
-
 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.12 Mycobacterium tuberculosis
-
-
-
2.3.2.12 Mycobacterium tuberculosis H37Rv
-
-
-
2.3.2.12 Mycolicibacterium smegmatis
-
-
-
2.3.2.12 Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2
-
 Mycolicibacterium smegmatis tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2
-
 Mycobacterium tuberculosis tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2
-
 Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2
-
 Mycobacterium tuberculosis H37Rv tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.2.12 ? x * 27600, LtdA, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 ? x * 28500, LtdA, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 ? x * 29800, LtdD, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 ? x * 38100, LtdE, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 ? x * 40200, LtdE, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 ? x * 44000, LtdB, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 ? x * 44900, LtdB, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 ? x * 46200, LtdF, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 ? x * 49600, LtdC, calculated from amino acid sequence Mycobacterium tuberculosis
2.3.2.12 ? x * 49700, LtdC, calculated from amino acid sequence Mycolicibacterium smegmatis
2.3.2.12 ? x * 49700, LtdG, calculated from amino acid sequence Mycolicibacterium smegmatis

Synonyms

EC Number Synonyms Comment Organism
2.3.2.12 L,D-transpeptidase
-
 Mycolicibacterium smegmatis
2.3.2.12 L,D-transpeptidase
-
 Mycobacterium tuberculosis
2.3.2.12 LDT
-
 Mycolicibacterium smegmatis
2.3.2.12 LDT
-
 Mycobacterium tuberculosis