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Literature summary extracted from

  • Ham, S.J.; Lee, S.Y.; Song, S.; Chung, J.R.; Choi, S.; Chung, J.
    Interaction between RING1 (R1) and the ubiquitin-like (UBL) domains is critical for the regulation of parkin activity (2016), J. Biol. Chem., 291, 1803-1816.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.27 PINK1 Parkin activation as an E3 ubiquitin ligase is regulated by PTEN-induced putative kinase 1 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.27 expressed in HEK-293T and HeLa cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.27 A46P the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens
2.3.2.27 C431S the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens
2.3.2.27 K27N the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens
2.3.2.27 K48A the mutant has higher autoubiquitination activity than the wild type Homo sapiens
2.3.2.27 R33Q the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens
2.3.2.27 R42P the mutant has higher autoubiquitination activity than the wild type Homo sapiens
2.3.2.27 T240R the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.27 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.27 additional information Homo sapiens Parkin E3 ligase has autoubiquitination activity ?
-
 ?
2.3.2.27 S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine Homo sapiens
-
 [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.27 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.27 additional information Parkin E3 ligase has autoubiquitination activity Homo sapiens ?
-
 ?
2.3.2.27 S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine
-
 Homo sapiens [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.27 E3 ubiquitin ligase
-
 Homo sapiens
2.3.2.27 Parkin
-
 Homo sapiens