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Literature summary extracted from

  • Wang, Z.; Wang, J.; Ren, G.; Li, Y.; Wang, X.
    Deletion of the genes waaC, waaF, or waaG in Escherichia coli W3110 disables the flagella biosynthesis (2016), J. Basic Microbiol., 56, 1021-1035.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.99.24 ADP-L-glycero-beta-D-manno-heptose + Kdo2-lipid A Escherichia coli
-
 ADP + Hep2-Kdo2-lipid A
-
 ?
2.4.99.24 ADP-L-glycero-beta-D-manno-heptose + Kdo2-lipid A Escherichia coli W3110 / ATCC 27325
-
 ADP + Hep2-Kdo2-lipid A
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.B64 Escherichia coli P25740
-
-
2.4.99.24 Escherichia coli P37692
-
-
2.4.99.24 Escherichia coli W3110 / ATCC 27325 P37692
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.99.24 ADP-L-glycero-beta-D-manno-heptose + Kdo2-lipid A
-
 Escherichia coli ADP + Hep2-Kdo2-lipid A
-
 ?
2.4.99.24 ADP-L-glycero-beta-D-manno-heptose + Kdo2-lipid A
-
 Escherichia coli W3110 / ATCC 27325 ADP + Hep2-Kdo2-lipid A
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.B64 lipopolysaccharide core biosynthesis protein
-
 Escherichia coli
2.4.1.B64 RfaG
-
 Escherichia coli
2.4.1.B64 WaaG
-
 Escherichia coli
2.4.99.24 ADP-heptose:LPS heptosyltransferase II
-
 Escherichia coli
2.4.99.24 heptosyltransferase II
-
 Escherichia coli
2.4.99.24 rfaF
-
 Escherichia coli
2.4.99.24 WaaF
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.4.1.B64 physiological function mutant strains lacking ADP-heptose-LPS heptosyltransferase 2, lipopolysaccharide heptosyltransferase 1 or glucosyltransferase WaaG only synthesize lipopolysaccharide with different lengths. Flagella are observed on the cell surface of the wild-type strain but not the mutant strains. 965genes in the WaaG deleltion mutant are significantly regulated compared to the control strain. Although there are significant transcriptional differences among the ADP-heptose-LPS heptosyltransferase 2, lipopolysaccharide heptosyltransferase 1 or glucosyltransferase mutant strains, genes related to flagella assembly and bacterial chemotaxis are significantly down-regulated in all three strains Escherichia coli
2.4.99.24 malfunction deletion of the enzyme's gene disables the flagella biosynthesis in Escherichia coli Escherichia coli