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Literature summary extracted from

  • Goyal, D.; Sharma, S.; Mahmood, A.
    Inhibition of dextransucrase activity in Streptococcus mutans by plant phenolics (2013), Indian J. Biochem. Biophys., 50, 48-53.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.5 gallic acid 80-90% inhibition at 4-5 mM, mixed-type inhibition in vitro Streptococcus mutans
2.4.1.5 additional information aqueous plant extracts from wood sticks of Acacia arabica, Azadirachta indica, Pongamia pinnata, and Salvadora persica are inhibitory. 5 mg Phenolic content in aqueous extracts of chewing stem sticks produce 35-40% inhibition of the enzyme activity, best inhibition at 7-7.5 for the phenolic compounds, and at pH 5.0-6.0 for plant extracts Streptococcus mutans
2.4.1.5 syringic acid 48% inhibition at 5 mM, mixed-type inhibition in vitro Streptococcus mutans
2.4.1.5 Tannic acid 80% inhibition at 0.2 mM, mixed-type inhibition in vitro Streptococcus mutans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.5 extracellular
-
 Streptococcus mutans
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.5 sucrose + [(1->6)-alpha-D-glucosyl]n Streptococcus mutans
-
 D-fructose + [(1->6)-alpha-D-glucosyl]n+1
-
 ?
2.4.1.5 sucrose + [(1->6)-alpha-D-glucosyl]n Streptococcus mutans MTCC 890
-
 D-fructose + [(1->6)-alpha-D-glucosyl]n+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.5 Streptococcus mutans
-
-
-
2.4.1.5 Streptococcus mutans MTCC 890
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.5 native enzyme from cell-free extracts by gel filtration Streptococcus mutans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.5 additional information the enzyme shows hydrolytic and glucosyl transferase activities with sucrose Streptococcus mutans ?
-
 ?
2.4.1.5 additional information the enzyme shows hydrolytic and glucosyl transferase activities with sucrose Streptococcus mutans MTCC 890 ?
-
 ?
2.4.1.5 sucrose + [(1->6)-alpha-D-glucosyl]n
-
 Streptococcus mutans D-fructose + [(1->6)-alpha-D-glucosyl]n+1
-
 ?
2.4.1.5 sucrose + [(1->6)-alpha-D-glucosyl]n
-
 Streptococcus mutans MTCC 890 D-fructose + [(1->6)-alpha-D-glucosyl]n+1
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.5 37
-
 assay at Streptococcus mutans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.5 6.8
-
 assay at Streptococcus mutans

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.5 0.35
-
 Tannic acid pH 6.8, 37°C Streptococcus mutans
2.4.1.5 1.6
-
 gallic acid pH 6.8, 37°C Streptococcus mutans
2.4.1.5 1.94
-
 syringic acid pH 6.8, 37°C Streptococcus mutans

General Information

EC Number General Information Comment Organism
2.4.1.5 metabolism the enzyme is responsible for sucrose metabolism exhibiting both hydrolysis and glucosyl transferase activities Streptococcus mutans
2.4.1.5 physiological function Streptococcus mutans causes dental caries in humans using sucrose for its growth Streptococcus mutans