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Literature summary extracted from

  • Fgaier, H.; Mustafa, I.H.; Awad, A.A.; Elkamel, A.
    Modeling the interaction between beta-amyloid aggregates and choline acetyltransferase activity and its relation with cholinergic dysfunction through two-enzyme/two-compartment model (2015), Comput. Math. Methods Med., 2015, 923762.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.6 beta-amyloid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.6 acetyl-CoA + choline Homo sapiens
-
 CoA + O-acetylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.6 Homo sapiens P28329
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.6 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.6 acetyl-CoA + choline
-
 Homo sapiens CoA + O-acetylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.6 ChAT
-
 Homo sapiens
2.3.1.6 choline acetyltransferase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.6 Homo sapiens enzyme activity is reduced significantly when neurons are exposed to high levels of beta-amyloid aggregates down

General Information

EC Number General Information Comment Organism
2.3.1.6 malfunction the reduction in levels of O-acetylcholine is one of the most significant physiological symptoms of Alzheimer's disease Homo sapiens