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Literature summary extracted from

  • May, E.E.; Leitao, A.; Tropsha, A.; Oprea, T.I.
    A systems chemical biology study of malate synthase and isocitrate lyase inhibition in Mycobacterium tuberculosis during active and NRP growth (2013), Comput. Biol. Chem., 47, 167-180.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.9 Bromopyruvate strong inhibitor Mycobacterium tuberculosis
2.3.3.9 glycolate weak inhibitor Mycobacterium tuberculosis
2.3.3.9 oxalate medium inhibitor Mycobacterium tuberculosis
2.3.3.9 phosphoenolpyruvate medium inhibitor Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.9 acetyl-CoA + H2O + glyoxylate Mycobacterium tuberculosis
-
 (S)-malate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.9 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.9 acetyl-CoA + H2O + glyoxylate
-
 Mycobacterium tuberculosis (S)-malate + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.3.9 glcB
-
 Mycobacterium tuberculosis
2.3.3.9 malate synthase
-
 Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.3.9 0.06
-
 Bromopyruvate pH and temperature not specified in the publication Mycobacterium tuberculosis
2.3.3.9 0.2
-
 phosphoenolpyruvate pH and temperature not specified in the publication Mycobacterium tuberculosis
2.3.3.9 0.4
-
 oxalate pH and temperature not specified in the publication Mycobacterium tuberculosis
2.3.3.9 0.9
-
 glycolate pH and temperature not specified in the publication Mycobacterium tuberculosis