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Literature summary extracted from

  • Grolla, A.A.; Travelli, C.; Genazzani, A.A.; Sethi, J.K.
    Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine (2016), Br. J. Pharmacol., 173, 2182-2194.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.12 A244M the mutation prevents inhibitor binding Homo sapiens
2.4.2.12 D219A inactive Homo sapiens
2.4.2.12 D219S the mutation leads to a switch in substrate affinity Homo sapiens
2.4.2.12 G217R the mutation prevents inhibitor binding Homo sapiens
2.4.2.12 G384A inactive Homo sapiens
2.4.2.12 H191R the mutation prevents inhibitor binding Homo sapiens
2.4.2.12 H247A inactive Homo sapiens
2.4.2.12 H247E the inactive mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization Homo sapiens
2.4.2.12 K342R inactive Homo sapiens
2.4.2.12 Q388R the mutation prevents dimerization Homo sapiens
2.4.2.12 R311D the inactive mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization Homo sapiens
2.4.2.12 R392A the inactive mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization Homo sapiens
2.4.2.12 S199D the mutation prevents dimerization and leads to loss of activity Homo sapiens
2.4.2.12 S200D the mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization. The mutation prevents dimerization Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 FK866 i.e. daporinad, (E)-N-[4-[1-(benzoyl)piperidin-4-yl]butyl]-3-pyridin-3-ylprop-2-enamide Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.12 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens P43490
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 3T3-L1 cell
-
 Homo sapiens
-
2.4.2.12 adipocyte
-
 Homo sapiens
-
2.4.2.12 amniotic epithelial cell
-
 Homo sapiens
-
2.4.2.12 B-16 cell
-
 Homo sapiens
-
2.4.2.12 breast cancer cell
-
 Homo sapiens
-
2.4.2.12 BT-549 cell
-
 Homo sapiens
-
2.4.2.12 cardiomyocyte
-
 Homo sapiens
-
2.4.2.12 cervical cancer cell
-
 Homo sapiens
-
2.4.2.12 chronic lymphocytic leukemia cell
-
 Homo sapiens
-
2.4.2.12 colorectal cancer cell
-
 Homo sapiens
-
2.4.2.12 DU-145 cell
-
 Homo sapiens
-
2.4.2.12 fibroblast
-
 Homo sapiens
-
2.4.2.12 glial cell
-
 Homo sapiens
-
2.4.2.12 glioma cell
-
 Homo sapiens
-
2.4.2.12 HCT-116 cell
-
 Homo sapiens
-
2.4.2.12 HeLa cell
-
 Homo sapiens
-
2.4.2.12 Hep-G2 cell
-
 Homo sapiens
-
2.4.2.12 hepatoma cell
-
 Homo sapiens
-
2.4.2.12 HIB-1B cell
-
 Homo sapiens
-
2.4.2.12 HMCB cell
-
 Homo sapiens
-
2.4.2.12 Huh-7 cell
-
 Homo sapiens
-
2.4.2.12 HUVEC cell
-
 Homo sapiens
-
2.4.2.12 LB-24_MEL cell
-
 Homo sapiens
-
2.4.2.12 leucocyte
-
 Homo sapiens
-
2.4.2.12 LS-180 cell
-
 Homo sapiens
-
2.4.2.12 macrophage
-
 Homo sapiens
-
2.4.2.12 MCF10A cell
-
 Homo sapiens
-
2.4.2.12 MCF7 cell
-
 Homo sapiens
-
2.4.2.12 MDA-MB-231 cell
-
 Homo sapiens
-
2.4.2.12 MDA-MB-468 cell
-
 Homo sapiens
-
2.4.2.12 melanocyte
-
 Homo sapiens
-
2.4.2.12 melanoma cell
-
 Homo sapiens
-
2.4.2.12 mesothelioma cell
-
 Homo sapiens
-
2.4.2.12 MeWo cell
-
 Homo sapiens
-
2.4.2.12 monocyte
-
 Homo sapiens
-
2.4.2.12 neuroblastoma cell
-
 Homo sapiens
-
2.4.2.12 neuron
-
 Homo sapiens
-
2.4.2.12 pancreatic beta cell
-
 Homo sapiens
-
2.4.2.12 pancreatic islet cell
-
 Homo sapiens
-
2.4.2.12 PC-12 cell
-
 Homo sapiens
-
2.4.2.12 peripheral blood lymphocyte
-
 Homo sapiens
-
2.4.2.12 pre-B cell
-
 Homo sapiens
-
2.4.2.12 prostate cancer cell
-
 Homo sapiens
-
2.4.2.12 sebocyte
-
 Homo sapiens
-
2.4.2.12 SH-SY5Y cell
-
 Homo sapiens
-
2.4.2.12 SK-N-BE cell
-
 Homo sapiens
-
2.4.2.12 SkMel-28 cell
-
 Homo sapiens
-
2.4.2.12 T-47D cell
-
 Homo sapiens
-
2.4.2.12 U-87 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 eNAMPT
-
 Homo sapiens
2.4.2.12 pre-B cell colony-enhancing factor
-
 Homo sapiens
2.4.2.12 Visfatin
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.4.2.12 ATP
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.2.12 Homo sapiens enzyme expression is decreased by insulin, PI3K and AKT inhibitors, quercetin down
2.4.2.12 Homo sapiens enzyme expression is increased by Ox-LDL, CTRP3, glucose, rosiglitazone, adipocyte differentiation, ATP, LPS, CoCl2, ischaemia, OGD, anti-CD38 and differentiation in CCL, oxidative stress (H2O2), hypoxia, TNF-alpha, interleukin-1beta, starvation, and C-peptide up

General Information

EC Number General Information Comment Organism
2.4.2.12 physiological function the enzyme is involved in cancer Homo sapiens