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Literature summary extracted from

  • Laurieri, N.; Kawamura, A.; Westwood, I.M.; Varney, A.; Morris, E.; Russell, A.J.; Stanley, L.A.; Sim, E.
    Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding (2014), BMC Pharmacol. Toxicol., 15, 68.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.5 expressed in Escherichia coli BL21(DE3)CodonPlus-RIL cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 additional information not inhibited by N-(3-(3,5-dimethylphenylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Homo sapiens P11245
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.5 Ni-NTA resin column chromatography, and gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-aminobenzoate 6% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-aminobenzoate
-
 ?
2.3.1.5 acetyl-CoA + 4-aminoveratrole 57% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-aminoveratrole
-
 ?
2.3.1.5 acetyl-CoA + 4-bromoaniline 72% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-bromoaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-chloroaniline 71% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-chloroaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-hexyloxyaniline 51% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-hexyloxyaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-iodoaniline 65% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-iodoaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-methoxyaniline 9% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-methoxyaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-phenoxyaniline 62% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-phenoxyaniline
-
 ?
2.3.1.5 acetyl-CoA + 5-aminosalicylate 64% activity compared to hydralazine Homo sapiens CoA + N-acetyl-5-aminosalicylate
-
 ?
2.3.1.5 acetyl-CoA + hydralazine 100% activity Homo sapiens CoA + N-acetylhydralazine
-
 ?
2.3.1.5 acetyl-CoA + isoniazid 62% activity compared to hydralazine Homo sapiens CoA + N-acetylisoniazid
-
 ?
2.3.1.5 acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate 3% activity compared to hydralazine Homo sapiens CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
 ?
2.3.1.5 acetyl-CoA + sulfamethazine 46% activity compared to hydralazine Homo sapiens CoA + N-acetylsulfamethazine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.5 arylamine N-acetyltransferase type 2
-
 Homo sapiens
2.3.1.5 NAT2
-
 Homo sapiens