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Literature summary extracted from

  • Lin, D.L.; Tran, T.; Adams, C.; Alam, J.Y.; Herron, S.R.; Tolmasky, M.E.
    Inhibitors of the aminoglycoside 6-N-acetyltransferase type Ib [AAC(6)-Ib] identified by in silico molecular docking (2013), Bioorg. Med. Chem. Lett., 23, 5694-5698.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.82 2-[5-[(4,6-dioxo-1,3-diphenyl-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-2-furyl]benzoic acid identified by in silico molecular docking, micromolar activity in inhibiting acetylation of kanamycin A Escherichia coli
2.3.1.82 4-[(2-[[1-(3-methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl]phenoxy)methyl]benzoic acid identified by in silico molecular docking, micromolar activity in inhibiting acetylation of kanamycin A Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.82 Escherichia coli Q6SJ71
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.82 acetyl-CoA + kanamycin A
-
 Escherichia coli CoA + N6'-acetylkanamycin A
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.82 0.012
-
 substrate kanamycin A, pH 7.5, temperature not specified in the publication Escherichia coli 2-[5-[(4,6-dioxo-1,3-diphenyl-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-2-furyl]benzoic acid
2.3.1.82 0.015
-
 substrate kanamycin A, pH 7.5, temperature not specified in the publication Escherichia coli 4-[(2-[[1-(3-methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl]phenoxy)methyl]benzoic acid
2.3.1.82 0.016
-
 substrate acetyl-CoA, pH 7.5, temperature not specified in the publication Escherichia coli 4-[(2-[[1-(3-methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl]phenoxy)methyl]benzoic acid
2.3.1.82 0.035
-
 substrate acetyl-CoA, pH 7.5, temperature not specified in the publication Escherichia coli 2-[5-[(4,6-dioxo-1,3-diphenyl-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-2-furyl]benzoic acid