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Literature summary extracted from

  • Dercksen, M.; IJlst, L.; Duran, M.; Mienie, L.J.; van Cruchten, A.; van der Westhuizen, F.H.; Wanders, R.J.
    Inhibition of N-acetylglutamate synthase by various monocarboxylic and dicarboxylic short-chain coenzyme A esters and the production of alternative glutamate esters (2014), Biochim. Biophys. Acta, 1842, 2510-2516.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.1 L-arginine
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.1 expressed in Escherichia coli BL21 AI cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.1 3-methylcrotonyl-CoA about 45% residual activity at 2.5 mM Homo sapiens
2.3.1.1 butyryl-CoA about 30% residual activity at 2.5 mM Homo sapiens
2.3.1.1 glutaryl-CoA about 50% residual activity at 2.5 mM Homo sapiens
2.3.1.1 isobutyryl-CoA about 45% residual activity at 2.5 mM Homo sapiens
2.3.1.1 isovaleryl-CoA about 50% residual activity at 2.5 mM Homo sapiens
2.3.1.1 methylmalonyl-CoA about 40% residual activity at 2.5 mM Homo sapiens
2.3.1.1 propionyl-CoA about 20% residual activity at 2.5 mM Homo sapiens
2.3.1.1 succinyl-CoA about 60% residual activity at 2.5 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.1 0.3
-
 acetyl-CoA at pH 8.5 and 30°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.1 acetyl-CoA + L-glutamate Homo sapiens
-
 CoA + N-acetyl-L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.1 acetyl-CoA + L-glutamate
-
 Homo sapiens CoA + N-acetyl-L-glutamate
-
 ?
2.3.1.1 butyryl-CoA + L-glutamate low activity compared to acetyl-CoA Homo sapiens CoA + N-butyryl-L-glutamate
-
 ?
2.3.1.1 additional information no activity with isobutyryl-CoA, isovaleryl-CoA, 3-methylcrotonyl-CoA, methylmalonyl-CoA, succinyl-CoA, and glutaryl-CoA Homo sapiens ?
-
 ?
2.3.1.1 propionyl-CoA + L-glutamate low activity compared to acetyl-CoA Homo sapiens CoA + N-propionyl-L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.1 N-acetylglutamate synthase
-
 Homo sapiens
2.3.1.1 NAGS
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.1 1.3
-
 butyryl-CoA at pH 8.5 and 30°C Homo sapiens
2.3.1.1 1.9
-
 isovaleryl-CoA at pH 8.5 and 30°C Homo sapiens