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Literature summary extracted from

  • Castell, A.; Short, F.L.; Evans, G.L.; Cookson, T.V.; Bulloch, E.M.; Joseph, D.D.; Lee, C.E.; Parker, E.J.; Baker, E.N.; Lott, J.S.
    The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition (2013), Biochemistry, 52, 1776-1787.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.18 expressed in Escherichia coli Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.18 D282A inactive Mycobacterium tuberculosis
2.4.2.18 G308L inactive Mycobacterium tuberculosis
2.4.2.18 H307A inactive Mycobacterium tuberculosis
2.4.2.18 N309A inactive Mycobacterium tuberculosis
2.4.2.18 T279A inactive Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Mycobacterium tuberculosis
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.18 Mycobacterium tuberculosis P9WFX5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.18 Ni-NTA column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.18 2-amino-2-pentenoate + 5-phospho-alpha-D-ribose 1-diphosphate good substrate Mycobacterium tuberculosis N-(5-phospho-D-ribosyl)-2-amino-2-pentenoate + diphosphate
-
 ?
2.4.2.18 2-aminoacrylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mycobacterium tuberculosis N-(5-phospho-D-ribosyl)-2-aminoacrylate + diphosphate
-
 ?
2.4.2.18 2-aminocrotonate + 5-phospho-alpha-D-ribose 1-diphosphate good substrate Mycobacterium tuberculosis N-(5-phospho-D-ribosyl)-2-aminocrotonate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mycobacterium tuberculosis N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 additional information no activity with 2-aminobutyrate Mycobacterium tuberculosis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.18 anthranilate phosphoribosyl transferase
-
 Mycobacterium tuberculosis
2.4.2.18 TrpD
-
 Mycobacterium tuberculosis