EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.67 | medicine | inhibitors 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone and 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone at 2.5 mg/kg shod significant, 47.9-51.7%, inhibition in the carrageenan-induced mouse paw edema test, stronger than that of prednisolone at 10 mg/kg | Mus musculus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.67 | gene Lpcat2, quantitative realtime PCR exprssion analysis | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.23 | 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone | potent inhibitor | Rattus norvegicus | |
2.3.1.23 | 3,4-dihydroxy-1,2-dimethoxy-5-methylbenzene | - |
Rattus norvegicus | |
2.3.1.23 | 3-acetoxy-2-methoxy-5-methyl-1,4-benzoquinone | - |
Rattus norvegicus | |
2.3.1.23 | 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | potent inhibitor | Rattus norvegicus | |
2.3.1.23 | 3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | - |
Rattus norvegicus | |
2.3.1.23 | dihydrofumigatin | i.e. 2-methoxy-1,3,4- trihydroxy-5-methylbenzene | Rattus norvegicus | |
2.3.1.23 | fumigatin | i.e. 3-hydroxy-2-methoxy-5-methyl-1,4-benzoquinone | Rattus norvegicus | |
2.3.1.23 | additional information | not inhibited by 2-methoxy-5-methyl-1,3,4-triacetoxybenzene and 1,4-diacetoxy-2-methoxy-5-methyl-3-tetradecanoyloxybenzene | Rattus norvegicus | |
2.3.1.67 | 1,4-diacetoxy-2-methoxy-5-methyl-3-tetradecanoyloxybenzene | - |
Mus musculus | |
2.3.1.67 | 2-methoxy-1,3,4-trihydroxy-5-methylbenzene | i.e. 2-methoxy-1,3,4-trihydroxy-5-methylbenzene, isolated from Penicillium sp. strain F33 | Mus musculus | |
2.3.1.67 | 2-methoxy-5-methyl-1,3,4-triacetoxybenzene | - |
Mus musculus | |
2.3.1.67 | 2-methoxy-5-methyl-3-octadecanoyloxy-1,4-benzoquinone | - |
Mus musculus | |
2.3.1.67 | 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone | derivative of a metabolite from Penicillium sp. F33 , strong inhibition. Compound also significantly suppresses the gene expression of lyso-PAF acetyltransferase/LPCAT2 in mouse bone marrow-derived macrophages stimulated by lipopolysaccharide | Mus musculus | |
2.3.1.67 | 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone | derivative of a metabolite from Penicillium sp. F33 , strong inhibition. Compound also significantly suppresses the gene expression of lyso-PAF acetyltransferase/LPCAT2 in mouse bone marrow-derived macrophages stimulated by lipopolysaccharide | Rattus norvegicus | |
2.3.1.67 | 3,4-dihydroxy-1,2-dimethoxy-5-methylbenzene | - |
Mus musculus | |
2.3.1.67 | 3-acetoxy-2-methoxy-5-methyl-1,4-benzoquinone | - |
Mus musculus | |
2.3.1.67 | 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | derivative of a metabolite from Penicillium sp. F33 , strong inhibition. Compound also significantly suppresses the gene expression of lyso-PAF acetyltransferase/LPCAT2 in mouse bone marrow-derived macrophages stimulated by lipopolysaccharide; not active against lipoxygenase and cyclooxygenases | Mus musculus | |
2.3.1.67 | 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | derivative of a metabolite from Penicillium sp. F33 , strong inhibition. Compound also significantly suppresses the gene expression of lyso-PAF acetyltransferase/LPCAT2 in mouse bone marrow-derived macrophages stimulated by lipopolysaccharide | Rattus norvegicus | |
2.3.1.67 | 3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | - |
Mus musculus | |
2.3.1.67 | 3-hydroxy-2-methoxy-5-methyl-1,4-benzoquinone | - |
Mus musculus | |
2.3.1.67 | Decanoic acid | - |
Mus musculus | |
2.3.1.67 | dihydrofumigatin | i.e. 2-methoxy-1,3,4-trihydroxy-5-methylbenzene, isolated from Penicillium sp. strain F33 | Mus musculus | |
2.3.1.67 | dodecanoic acid | - |
Mus musculus | |
2.3.1.67 | additional information | inhibition of lipopolysaccharide-induced platelet activating factor production and gene expression of lysophosphatidylcholine acyltransferase (LPCAT2)/lyso-PAF acetyltransferase by synthetic fumigatin derivatives, compound stability and inhibitory potencies, synthesis and evaluation, overview. Dihydrofumigatin is isolated and identified from Penicillium sp. strain F33. In addition to the efficacy to inhibit the function of lyso/PAF acetyltransferase/LPCAT2, 3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone, 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone, and 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone also inhibit the expression of LPCAT2 mRNA | Mus musculus | |
2.3.1.67 | myristic acid | - |
Mus musculus | |
2.3.1.67 | octanoic acid | - |
Mus musculus | |
2.3.1.67 | palmitic acid | - |
Mus musculus | |
2.3.1.67 | tetradecanoic acid | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.23 | microsome | - |
Rattus norvegicus | - |
- |
2.3.1.67 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.23 | acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | Rattus norvegicus | - |
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.23 | Rattus norvegicus | - |
- |
- |
2.3.1.67 | Mus musculus | - |
- |
- |
2.3.1.67 | Mus musculus | Q8BYI6 | gene Lpcat2; gene Lpcat2 | - |
2.3.1.67 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.23 | spleen | - |
Rattus norvegicus | - |
2.3.1.67 | macrophage | bone marrow-derived | Mus musculus | - |
2.3.1.67 | spleen | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.23 | acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | - |
Rattus norvegicus | CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.23 | acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase | - |
Rattus norvegicus |
2.3.1.23 | lyso-PAF acetyltransferase | - |
Rattus norvegicus |
2.3.1.67 | acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase | - |
Mus musculus |
2.3.1.67 | acetyl-CoA:lyso-PAF acetyltransferase | - |
Mus musculus |
2.3.1.67 | acetyl-CoA:lyso-PAF acetyltransferase | - |
Rattus norvegicus |
2.3.1.67 | LPCAT2 | - |
Mus musculus |
2.3.1.67 | LPCAT2 | - |
Rattus norvegicus |
2.3.1.67 | lyso-PAF acetyltransferase | - |
Mus musculus |
2.3.1.67 | lysophosphatidylcholine acyltransferase (LPCAT2)/lyso-PAF acetyltransferase | - |
Mus musculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.67 | 37 | - |
assay at | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.67 | 6.9 | - |
assay at | Mus musculus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.23 | 0.003 | - |
at pH 6.9 and 37°C | Rattus norvegicus | 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | |
2.3.1.23 | 0.02 | - |
at pH 6.9 and 37°C | Rattus norvegicus | 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone | |
2.3.1.23 | 0.101 | - |
at pH 6.9 and 37°C | Rattus norvegicus | dihydrofumigatin | |
2.3.1.23 | 0.109 | - |
at pH 6.9 and 37°C | Rattus norvegicus | fumigatin | |
2.3.1.23 | 0.139 | - |
at pH 6.9 and 37°C | Rattus norvegicus | 3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | |
2.3.1.23 | 0.166 | - |
at pH 6.9 and 37°C | Rattus norvegicus | 3,4-dihydroxy-1,2-dimethoxy-5-methylbenzene | |
2.3.1.23 | 0.391 | - |
at pH 6.9 and 37°C | Rattus norvegicus | 3-acetoxy-2-methoxy-5-methyl-1,4-benzoquinone | |
2.3.1.67 | 0.003 | - |
pH 6.9, 37°C | Rattus norvegicus | 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | |
2.3.1.67 | 0.003 | - |
pH 6.9, 37°C | Mus musculus | 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | |
2.3.1.67 | 0.02 | - |
pH 6.9, 37°C | Rattus norvegicus | 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone | |
2.3.1.67 | 0.02 | - |
pH 6.9, 37°C | Mus musculus | 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone | |
2.3.1.67 | 0.101 | - |
pH 6.9, 37°C | Mus musculus | 2-methoxy-1,3,4-trihydroxy-5-methylbenzene | |
2.3.1.67 | 0.109 | - |
pH 6.9, 37°C | Mus musculus | 3-hydroxy-2-methoxy-5-methyl-1,4-benzoquinone | |
2.3.1.67 | 0.121 | - |
pH 6.9, 37°C | Mus musculus | 3-acetoxy-2-methoxy-5-methyl-1,4-benzoquinone | |
2.3.1.67 | 0.139 | - |
pH 6.9, 37°C | Mus musculus | 3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone | |
2.3.1.67 | 0.166 | - |
pH 6.9, 37°C | Mus musculus | 3,4-dihydroxy-1,2-dimethoxy-5-methylbenzene | |
2.3.1.67 | 0.183 | - |
pH 6.9, 37°C | Mus musculus | myristic acid | |
2.3.1.67 | 0.183 | - |
pH 6.9, 37°C | Rattus norvegicus | tetradecanoic acid | |
2.3.1.67 | 0.391 | - |
pH 6.9, 37°C | Mus musculus | 2-methoxy-5-methyl-3-octadecanoyloxy-1,4-benzoquinone | |
2.3.1.67 | 0.419 | - |
pH 6.9, 37°C | Mus musculus | dodecanoic acid | |
2.3.1.67 | 0.5 | - |
pH 6.9, 37°C | Mus musculus | palmitic acid | |
2.3.1.67 | 0.5 | - |
pH 6.9, 37°C | Mus musculus | octanoic acid | |
2.3.1.67 | 0.5 | - |
pH 6.9, 37°C | Mus musculus | Decanoic acid | |
2.3.1.67 | 0.5 | - |
pH 6.9, 37°C | Mus musculus | 2-methoxy-5-methyl-1,3,4-triacetoxybenzene | |
2.3.1.67 | 0.5 | - |
pH 6.9, 37°C | Mus musculus | 1,4-diacetoxy-2-methoxy-5-methyl-3-tetradecanoyloxybenzene |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.3.1.67 | Mus musculus | 3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone, 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone, and 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone also inhibit the expression of the enzyme mRNA | down |
2.3.1.67 | Mus musculus | fatty acid esters of fumigatin reduce lipopolysaccharide-stimulated transcription of lyso-PAF acetyltransferase/LPCAT2 mRNA in bone marrow-derived macrophages | additional information |
2.3.1.67 | Mus musculus | stimulation of enzyme expression by lipopolysaccharides | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.23 | metabolism | key enzyme in platelet-activating factor biosynthesis | Rattus norvegicus |
2.3.1.67 | physiological function | in inflammatory and allergic processes, platelet-activating factor, PAF, is biosynthesized in specific enzymatic reactions, which involve acetyl-CoA:lyso-PAF acetyltransferases | Mus musculus |