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Literature summary extracted from

  • Kessler, M.; Berger, I.M.; Just, S.; Rottbauer, W.
    Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish (2015), Basic Res. Cardiol., 110, 14.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.61 gene zdlst, DNA and amino acid sequence determination and analysis, genetic fine-mapping, and quantitative real-time PCR enzyme expression analysis Danio rerio

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.61 additional information generation of enzyme knockout mutants, the zebrafish mutant schneckentempo, phenotype ste, exhibits bradycardia. The ste mutation is a guanine to adenine nucleotide transition in the splice donor site of intron 5 of the zdlst gene, ENSDARG00000014230 Danio rerio

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.61 mitochondrion the enzyme localizes to the mitochondrial matrix Danio rerio 5739
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine Danio rerio
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 CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.61 Danio rerio
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 gene zdlst
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.61 heart
-
 Danio rerio
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
 Danio rerio CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.61 dihydrolipoyl succinyltransferase
-
 Danio rerio
2.3.1.61 DLST
-
 Danio rerio

General Information

EC Number General Information Comment Organism
2.3.1.61 malfunction loss of dihydrolipoyl succinyltransferase leads to reduced resting heart rate in the zebrafish, enzyme deficiency causes the embryonic lethal, recessive zebrafish mutant schneckentempo ste phenotype. Homozygous ste mutants exhibit a severely reduced resting heart rate with normal atrio-ventricular conduction and contractile function. External electrical pacing reveals that defective excitation generation in cardiac pacemaker cells underlies bradycardia in ste-/- mutants. ATP levels are significantly diminished in ste-/- mutant embryos Danio rerio
2.3.1.61 metabolism dihydrolipoyl succinyltransferase catalyzes the citric acid cycle within the 2-oxoglutarate dehydrogenase complex Danio rerio
2.3.1.61 physiological function the mitochondrial enzyme dihydrolipoyl succinyltransferase is an essential player in the citric acid cycle that warrants proper ATP production. The enzyme plays an essential role in the modulation of the vertebrate heart rate by controlling ATP production in the heart Danio rerio