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Literature summary extracted from

  • Tada, T.; Miyoshi-Akiyama, T.; Dahal, R.K.; Mishra, S.K.; Shimada, K.; Ohara, H.; Kirikae, T.; Pokhrel, B.M.
    Identification of a novel 6-N-aminoglycoside acetyltransferase, AAC(6)-Iak, from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia (2014), Antimicrob. Agents Chemother., 58, 6324-6327.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.82 0.004
-
sisomicin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.01
-
neomycin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.016
-
tobramycin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.024
-
dibekacin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.03
-
kanamycin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.032
-
amikacin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.036
-
arbekacin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.044
-
isepamicin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.07
-
netilmicin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.82 Stenotrophomonas maltophilia V5XKM9
-
-
2.3.1.82 Stenotrophomonas maltophilia IOMTU250 V5XKM9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.82 acetyl-CoA + amikacin
-
Stenotrophomonas maltophilia CoA + 6'-N-acetylamikacin
-
?
2.3.1.82 acetyl-CoA + amikacin
-
Stenotrophomonas maltophilia IOMTU250 CoA + 6'-N-acetylamikacin
-
?
2.3.1.82 acetyl-CoA + arbekacin
-
Stenotrophomonas maltophilia CoA + 6'-N-acetylarbekacin
-
?
2.3.1.82 acetyl-CoA + arbekacin
-
Stenotrophomonas maltophilia IOMTU250 CoA + 6'-N-acetylarbekacin
-
?
2.3.1.82 acetyl-CoA + dibekacin
-
Stenotrophomonas maltophilia CoA + 6'-N-acetyldibekacin
-
?
2.3.1.82 acetyl-CoA + dibekacin
-
Stenotrophomonas maltophilia IOMTU250 CoA + 6'-N-acetyldibekacin
-
?
2.3.1.82 acetyl-CoA + isepamicin
-
Stenotrophomonas maltophilia CoA + 6'-N-acetylisepamicin
-
?
2.3.1.82 acetyl-CoA + kanamycin
-
Stenotrophomonas maltophilia CoA + 6'-N-acetylkanamycin
-
?
2.3.1.82 acetyl-CoA + kanamycin
-
Stenotrophomonas maltophilia IOMTU250 CoA + 6'-N-acetylkanamycin
-
?
2.3.1.82 acetyl-CoA + neomycin
-
Stenotrophomonas maltophilia CoA + 6'-N-acetylneomycin
-
?
2.3.1.82 acetyl-CoA + netilmicin
-
Stenotrophomonas maltophilia CoA + 6'-N-acetylnetilmicin
-
?
2.3.1.82 acetyl-CoA + sisomicin
-
Stenotrophomonas maltophilia CoA + 6'-N-acetylsisomicin
-
?
2.3.1.82 acetyl-CoA + tobramycin
-
Stenotrophomonas maltophilia CoA + 6'-N-acetyltobramycin
-
?
2.3.1.82 additional information no substrates: apramycin, gentamicin, or lividomycin Stenotrophomonas maltophilia ?
-
?
2.3.1.82 additional information no substrates: apramycin, gentamicin, or lividomycin Stenotrophomonas maltophilia IOMTU250 ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.82 AAC(6)-Iak
-
Stenotrophomonas maltophilia
2.3.1.82 aminoglycoside N(6')-acetyltransferase type 1
-
Stenotrophomonas maltophilia

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.1.82 0.04
-
kanamycin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.05
-
isepamicin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.08
-
tobramycin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.11
-
amikacin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.16
-
sisomicin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.25
-
dibekacin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.3
-
netilmicin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.32
-
neomycin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 0.57
-
arbekacin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia

General Information

EC Number General Information Comment Organism
2.3.1.82 physiological function Escherichia coli transformed with a plasmid containing aac(6')-Iak exhibits decreased susceptibility to arbekacin, dibekacin, neomycin, netilmicin, sisomicin, and tobramycin Stenotrophomonas maltophilia

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.3.1.82 1
-
kanamycin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 1
-
isepamicin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 4
-
amikacin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 4
-
netilmicin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 6
-
tobramycin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 10
-
dibekacin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 16
-
arbekacin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 34
-
neomycin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia
2.3.1.82 38
-
sisomicin pH not specified in the publication, temperature not specified in the publication Stenotrophomonas maltophilia