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Literature summary extracted from

  • Schwab, N.; Skopp, G.
    Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide (2014), Anal. Bioanal. Chem., 406, 2325-2332.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 kaempferol the formation of ethylglucuronoside is inhibited by the flavonoids for all enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition Homo sapiens
2.4.1.17 additional information the formation of ethylglucuronoside is inhibited by the flavonoids kaempferol and quercetin for all enzymes except for UGT2B15, mechanism-based inhibition Homo sapiens
2.4.1.17 quercetin the formation of ethylglucuronoside is inhibited by the flavonoids for all enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information Michaelis-Menten kinetics, overview Homo sapiens
2.4.1.17 8.03
-
 ethanol pH 7.4, 37°C, enzyme UGT2B15 Homo sapiens
2.4.1.17 10.33
-
 ethanol pH 7.4, 37°C, enzyme UGT1A1 Homo sapiens
2.4.1.17 12.05
-
 ethanol pH 7.4, 37°C, enzyme UGT1A4 Homo sapiens
2.4.1.17 21.46
-
 ethanol pH 7.4, 37°C, enzyme UGT1A6 Homo sapiens
2.4.1.17 26.17
-
 ethanol pH 7.4, 37°C, enzyme UGT1A9 Homo sapiens
2.4.1.17 32.41
-
 ethanol pH 7.4, 37°C, enzyme UGT2B7 Homo sapiens
2.4.1.17 35.07
-
 ethanol pH 7.4, 37°C, enzyme UGT2B10 Homo sapiens
2.4.1.17 40.04
-
 ethanol pH 7.4, 37°C, enzyme UGT1A3 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 additional information enzyme ion suppression Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 UDP-glucuronate + ethanol Homo sapiens
-
 UDP + ethyl beta-D-glucuronoside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens O60656 UGT1A9; gene UGT1A9
-
2.4.1.17 Homo sapiens P16662 UGT2B7; gene UGT2B7
-
2.4.1.17 Homo sapiens P19224 UGT1A6; gene UGT1A6
-
2.4.1.17 Homo sapiens P22309 UGT1A1
-
2.4.1.17 Homo sapiens P22310 UGT1A4; gene UGT1A4
-
2.4.1.17 Homo sapiens P35503 UGT1A3; gene UGT1A3
-
2.4.1.17 Homo sapiens P36537 UGT2B10; gene UGT2B10
-
2.4.1.17 Homo sapiens P54855 UGT2B15; gene UGT2B15
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 commercial preparation recombinant Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
 Vmax values for all enzymes with ethanol Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + ethanol
-
 Homo sapiens UDP + ethyl beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + ethanol high activity Homo sapiens UDP + ethyl beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + ethanol highest activity with enzymes UGT1A9 and UGT2B7 Homo sapiens UDP + ethyl beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT1A1
-
 Homo sapiens
2.4.1.17 UGT1A3
-
 Homo sapiens
2.4.1.17 UGT1A4
-
 Homo sapiens
2.4.1.17 UGT1A6
-
 Homo sapiens
2.4.1.17 UGT1A9
-
 Homo sapiens
2.4.1.17 UGT2B10
-
 Homo sapiens
2.4.1.17 UGT2B15
-
 Homo sapiens
2.4.1.17 UGT2B7
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.002
-
 quercetin pH 7.4, 37°C, enzyme UGT1A1 Homo sapiens
2.4.1.17 0.0099
-
 kaempferol pH 7.4, 37°C, enzyme UGT2B10 Homo sapiens
2.4.1.17 0.0112
-
 kaempferol pH 7.4, 37°C, enzyme UGT2B7 Homo sapiens
2.4.1.17 0.015
-
 quercetin pH 7.4, 37°C, enzyme UGT1A3 Homo sapiens
2.4.1.17 0.0301
-
 quercetin pH 7.4, 37°C, enzyme UGT1A9 Homo sapiens
2.4.1.17 0.0326
-
 kaempferol pH 7.4, 37°C, enzyme UGT1A6 Homo sapiens
2.4.1.17 0.0372
-
 kaempferol pH 7.4, 37°C, enzyme UGT1A1 Homo sapiens
2.4.1.17 0.044
-
 kaempferol pH 7.4, 37°C, enzyme UGT1A9 Homo sapiens
2.4.1.17 0.0623
-
 kaempferol pH 7.4, 37°C, enzyme UGT1A3 Homo sapiens
2.4.1.17 0.0711
-
 quercetin pH 7.4, 37°C, enzyme UGT1A6 Homo sapiens
2.4.1.17 0.0931
-
 quercetin pH 7.4, 37°C, enzyme UGT2B10 Homo sapiens
2.4.1.17 0.1132
-
 quercetin pH 7.4, 37°C, enzyme UGT1A4 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.17 0.003
-
 pH 7.4, 37°C, enzyme UGT1A1 Homo sapiens quercetin
2.4.1.17 0.0104
-
 pH 7.4, 37°C, enzyme UGT2B10 Homo sapiens kaempferol
2.4.1.17 0.0138
-
 pH 7.4, 37°C, enzyme UGT2B7 Homo sapiens kaempferol
2.4.1.17 0.0149
-
 pH 7.4, 37°C, enzyme UGT1A6 Homo sapiens kaempferol
2.4.1.17 0.0178
-
 pH 7.4, 37°C, enzyme UGT1A3 Homo sapiens quercetin
2.4.1.17 0.0252
-
 pH 7.4, 37°C, enzyme UGT1A3 Homo sapiens kaempferol
2.4.1.17 0.0336
-
 pH 7.4, 37°C, enzyme UGT1A1 Homo sapiens kaempferol
2.4.1.17 0.0379
-
 pH 7.4, 37°C, enzyme UGT1A9 Homo sapiens quercetin
2.4.1.17 0.0385
-
 pH 7.4, 37°C, enzyme UGT1A9 Homo sapiens kaempferol
2.4.1.17 0.109
-
 pH 7.4, 37°C, enzyme UGT1A4 Homo sapiens quercetin
2.4.1.17 0.1526
-
 pH 7.4, 37°C, enzyme UGT1A6 Homo sapiens quercetin

General Information

EC Number General Information Comment Organism
2.4.1.17 evolution UGT enzymes are genetically polymorphic Homo sapiens