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Literature summary extracted from

  • Pathak, S.; Lakhwani, D.; Gupta, P.; Mishra, B.; Shukla, S.; Asif, M.; Trivedi, P.
    Comparative transcriptome analysis using high papaverine mutant of Papaver somniferum reveals pathway and uncharacterized steps of papaverine biosynthesis (2013), PLoS ONE, 8, e65622.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.116 S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine Papaver somniferum
-
 S-Adenosyl-L-homocysteine + (S)-reticuline
-
 ?
2.1.1.128 S-adenosyl-L-methionine + (RS)-norcoclaurine Papaver somniferum
-
 S-adenosyl-L-homocysteine + (RS)-coclaurine
-
 ?
2.1.1.140 S-adenosyl-L-methionine + (S)-coclaurine Papaver somniferum
-
 S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.116 Papaver somniferum
-
 cultivar BR086
-
2.1.1.128 Papaver somniferum Q6WUC1 cultivar BR086
-
2.1.1.140 Papaver somniferum Q7XB08
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.116 S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine
-
 Papaver somniferum S-Adenosyl-L-homocysteine + (S)-reticuline
-
 ?
2.1.1.128 S-adenosyl-L-methionine + (RS)-norcoclaurine
-
 Papaver somniferum S-adenosyl-L-homocysteine + (RS)-coclaurine
-
 ?
2.1.1.140 S-adenosyl-L-methionine + (S)-coclaurine
-
 Papaver somniferum S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.116 (S)-3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase
-
 Papaver somniferum
2.1.1.116 4'OMT
-
 Papaver somniferum
2.1.1.128 (S)-norcoclaurine-6-O-methyltransferase
-
 Papaver somniferum
2.1.1.128 6OMT
-
 Papaver somniferum
2.1.1.140 CNMT
-
 Papaver somniferum
2.1.1.140 coclaurine-N-methyltransferase
-
 Papaver somniferum

Expression

EC Number Organism Comment Expression
2.1.1.128 Papaver somniferum enzyme expression is upregulated in the high papaverine mutant pap1 up