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Literature summary extracted from

  • Cabezas, A.; Ribeiro, J.; Rodrigues, J.; Lopez-Villamizar, I.; Fernandez, A.; Canales, J.; Pinto, R.; Costas, M.; Cameselle, J.
    Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent adpribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase (2015), PLoS ONE, 10, e0118680.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.1.13 substrate docking on a homology model suggests possible interactions of ADP-ribose with seven residues located, with one exception (Cys253), either within the metallo-dependent phosphatases signature (Gln27, Asn110, His111), or in unique structural regions of the ADPRibase-Mn family: s2s3 (Phe37 and Arg43) and h7h8 (Phe210), around the active site entrance. Residue Phe37 is needed for ADP-ribose preference without catalytic effect. Arg43 is essential for catalysis. Cys253 is hindering for cADPR phosphohydrolase Homo sapiens
3.6.1.53 substrate docking on a homology model of human ADPRibase-Mn suggests possible interactions of ADP-ribose with residue Cys253, within the metallo-dependent phosphatases signature with Gln27, Asn110, His111, or in unique structural regions of the ADPRibase-Mn family, residues Phe37 and Arg43 and Phe210 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.13 C253A mutant displays a tenfold increased efficiency for cADP-ribose, with no or modest effect on the other substrates Homo sapiens
3.6.1.13 F210A lowers 40-70fold the catalytic efficiency for ADP-ribose, CDP-choline and 2',3'-cAMP hydrolysis, and 500fold for cADP-ribose Homo sapiens
3.6.1.13 F37A 19fold increased Km for ADP-ribose, with only a 2-3fold increase of the CDP-choline and 2',3'-cAMP Km values Homo sapiens
3.6.1.13 F37A/L196A mutation lessens the relative preference for ADP-ribose versus cADP-ribose Homo sapiens
3.6.1.13 F37A/L196F mutation lessens the relative preference for ADP-ribose versus cADP-ribose Homo sapiens
3.6.1.13 F37A/L196F/C253A cyclic ADP-ribose is the best substrate for the mutant Homo sapiens
3.6.1.13 F37Y similar kinetic parameters as the wild type Homo sapiens
3.6.1.13 H111A marked efficiency decrease with all substrates except 2',3'-cAMP Homo sapiens
3.6.1.13 H111N marked efficiency decrease with all substrates except 2',3'-cAMP Homo sapiens
3.6.1.13 L196A mutation causes only a modest 2-5fold decrease of catalytic efficiency with the four substrates tested Homo sapiens
3.6.1.13 N110A 100-250fold reduction in catalytic efficiency for the hydrolysis of CDP-choline or 2',3'-cAMP Homo sapiens
3.6.1.13 Q27H mutation reduces 11-13-fold the catalytic efficiency of the hydrolysis of ADP-ribose, CDP-choline or 2',3'-cAMP, and 27fold the hydrolysis of cADP-ribose Homo sapiens
3.6.1.13 R43A drastic decrease of catalytic efficiency Homo sapiens
3.6.1.53 C253A 10fold increase of the catalytic efficiency for cyclic ADP-ribose Homo sapiens
3.6.1.53 C253A Cys253 is hindering for cADPR phosphohydrolase activity, specific tenfold gain of efficiency with cyclic ADP-ribose Homo sapiens
3.6.1.53 F210A mutation lowers 40-70fold the catalytic efficiency for ADP-ribose, CDP-choline and 2',3'-cAMP hydrolysis, and 500fold for cyclic ADP-ribose Homo sapiens
3.6.1.53 F37A Phe37 is needed for ADP-ribose preference without catalytic effect Homo sapiens
3.6.1.53 F37A/L196A modest enhancement of the inhibitory effect over that of the F37A point mutation Homo sapiens
3.6.1.53 F37A/L196F modest enhancement of the inhibitory effect over that of the F37A point mutation Homo sapiens
3.6.1.53 F37A/L196F/C253A cyclic ADP-ribose is the best substrate, with a 8fold increase in catalytic efficiency compared to wild-type Homo sapiens
3.6.1.53 F37Y kinetic parameters similar to wild-type Homo sapiens
3.6.1.53 H111A marked decrease in efficiency with all substrates except 2',3'-cAMP Homo sapiens
3.6.1.53 H111N marked decrease in efficiency with all substrates except 2',3'-cAMP Homo sapiens
3.6.1.53 L196A modest 2-5fold decrease of catalytic efficiency with the substrates tested Homo sapiens
3.6.1.53 N110A reduction of catalytic efficiency is stronger for the hydrolysis of CDP-choline or 2',3'-cAMP than for the hydrolysis of ADP-ribose or cADPR. The decrease of kcat value is stronger for the hydrolysis of 2',3'-cAMP Homo sapiens
3.6.1.53 Q27H for ADP-ribose, modest negative effects of similar magnitude in catalysis and in substrate binding. For CDP-choline, the substitution affects only binding. For 2',3'-cAMP, the substitution affects catalysis, not binding Homo sapiens
3.6.1.53 R43A Arg43 is essential for catalysis, drastic efficiency loss of the mutant Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.13 0.06
-
ADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.077
-
ADP-ribose mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.078
-
ADP-ribose mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.094
-
ADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.115
-
ADP-ribose mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.13
-
ADP-ribose mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.14
-
ADP-ribose mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.2
-
cADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.2
-
ADP-ribose mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.29
-
ADP-ribose mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.35
-
CDP-choline wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.43
-
CDP-choline mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.46
-
cADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.47
-
CDP-choline mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.5
-
CDP-choline mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.78
-
cADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.97
-
CDP-choline mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.05
-
2',3'-cAMP mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.15
-
ADP-ribose mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.15
-
ADP-ribose mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.2
-
ADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.25
-
CDP-choline mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.25
-
2',3'-cAMP mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.5
-
CDP-choline mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.6
-
ADP-ribose mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.7
-
CDP-choline mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.8
-
2',3'-cAMP mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.1
-
ADP-ribose mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.3
-
2',3'-cAMP mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.4
-
2',3'-cAMP wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.5
-
2',3'-cAMP mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.6
-
2',3'-cAMP mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.7
-
CDP-choline mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.7
-
CDP-choline mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 3.4
-
2',3'-cAMP mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 4
-
CDP-choline mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 4.8
-
2',3'-cAMP mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 5.1
-
2',3'-cAMP mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 5.2
-
2',3'-cAMP mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 7.1
-
2',3'-cAMP mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 7.5
-
CDP-choline mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 7.6
-
2',3'-cAMP mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.13 7.6
-
2',3'-cAMP mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 9
-
CDP-choline mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 11
-
CDP-choline mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.06
-
ADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.077
-
ADP-ribose mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.078
-
ADP-ribose mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.094
-
ADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.115
-
ADP-ribose mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.13
-
ADP-ribose mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.14
-
ADP-ribose mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.2
-
cyclic ADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.2
-
ADP-ribose mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.29
-
ADP-ribose mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.35
-
CDP-choline wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.43
-
CDP-choline mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.46
-
cyclic ADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.47
-
CDP-choline mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.5
-
CDP-choline mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.78
-
cyclic ADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.97
-
CDP-choline mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.05
-
2',3'-cAMP mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.15
-
ADP-ribose mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.15
-
ADP-ribose mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.2
-
ADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.25
-
CDP-choline mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.25
-
2',3'-cAMP mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.5
-
CDP-choline mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.6
-
ADP-ribose mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.7
-
CDP-choline mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.8
-
2',3'-cAMP mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.1
-
ADP-ribose mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.3
-
2',3'-cAMP mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.4
-
2',3'-cAMP wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.5
-
2',3'-cAMP mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.6
-
2',3'-cAMP mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.7
-
CDP-choline mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.7
-
CDP-choline mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 3.4
-
2',3'-cAMP mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 4
-
CDP-choline mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 4.8
-
2',3'-cAMP mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 5.1
-
2',3'-cAMP mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 5.2
-
2',3'-cAMP mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 7.1
-
2',3'-cAMP mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 7.5
-
CDP-choline mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 7.6
-
2',3'-cAMP mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 7.6
-
2',3'-cAMP mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 9
-
CDP-choline mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 11
-
CDP-choline mutant F210A, pH 7.5, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.13 Homo sapiens W0NWJ0
-
-
3.6.1.53 Homo sapiens W0NWJ0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.53 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.13 2',3'-cAMP + H2O
-
Homo sapiens 3'AMP
-
?
3.6.1.13 ADP-ribose + H2O
-
Homo sapiens AMP + D-ribose 5-phosphate
-
?
3.6.1.13 cADP-ribose + H2O
-
Homo sapiens N1-(5-phosphoribosyl)-AMP + phosphate
-
?
3.6.1.13 CDP-choline + H2O
-
Homo sapiens CMP + choline phosphate
-
?
3.6.1.53 2',3'-cAMP + H2O
-
Homo sapiens ?
-
?
3.6.1.53 ADP-ribose + H2O
-
Homo sapiens AMP + D-ribose 5-phosphate
-
?
3.6.1.53 CDP-choline + H2O
-
Homo sapiens CMP + phosphocholine
-
?
3.6.1.53 cyclic ADP-ribose + H2O
-
Homo sapiens N1-(5-phosphoribosyl)-AMP
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6.1.13 0.003
-
ADP-ribose mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.025
-
CDP-choline mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.11
-
2',3'-cAMP mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.47
-
ADP-ribose mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.95
-
2',3'-cAMP mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 2 8 2',3'-cAMP mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.2
-
CDP-choline mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.3
-
ADP-ribose mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 2.7
-
2',3'-cAMP mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.13 3 6 2',3'-cAMP mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 3.2
-
cADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 4.3
-
ADP-ribose mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 4.3
-
2',3'-cAMP mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 5.3
-
CDP-choline mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 5.7
-
CDP-choline mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 7
-
ADP-ribose mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 7.4
-
2',3'-cAMP mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 8
-
ADP-ribose mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 8.9
-
cADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 10
-
ADP-ribose mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 13
-
ADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 14
-
ADP-ribose mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 16
-
cADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 16
-
ADP-ribose mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 19
-
ADP-ribose mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.13 19
-
2',3'-cAMP mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 20
-
2',3'-cAMP mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 25
-
CDP-choline mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 26
-
CDP-choline mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 29
-
CDP-choline mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 30
-
2',3'-cAMP mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 33
-
CDP-choline mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 34
-
2',3'-cAMP mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 35
-
ADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 37
-
CDP-choline mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 39
-
CDP-choline mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 50
-
CDP-choline wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 50
-
CDP-choline mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.13 50
-
ADP-ribose mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 60
-
2',3'-cAMP wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 70
-
2',3'-cAMP mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 76
-
CDP-choline mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 79
-
CDP-choline mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 83
-
2',3'-cAMP mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 97
-
ADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.003
-
ADP-ribose mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.025
-
CDP-choline mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.11
-
2',3'-cAMP mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.47
-
ADP-ribose mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.95
-
2',3'-cAMP mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 2 8 2',3'-cAMP mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.2
-
CDP-choline mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.3
-
ADP-ribose mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 2.7
-
2',3'-cAMP mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 3 6 2',3'-cAMP mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 3.2
-
cyclic ADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 4.3
-
ADP-ribose mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 4.3
-
2',3'-cAMP mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 5.3
-
CDP-choline mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 5.7
-
CDP-choline mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 7
-
ADP-ribose mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 7.4
-
2',3'-cAMP mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 8
-
ADP-ribose mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 8.9
-
cyclic ADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 10
-
ADP-ribose mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 13
-
ADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 14
-
ADP-ribose mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 16
-
cyclic ADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 16
-
ADP-ribose mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 19
-
ADP-ribose mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 19
-
2',3'-cAMP mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 20
-
2',3'-cAMP mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 25
-
CDP-choline mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 26
-
CDP-choline mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 29
-
CDP-choline mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 30
-
2',3'-cAMP mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 33
-
CDP-choline mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 34
-
2',3'-cAMP mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 35
-
ADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 37
-
CDP-choline mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 39
-
CDP-choline mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 50
-
CDP-choline wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 50
-
CDP-choline mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 50
-
ADP-ribose mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 60
-
2',3'-cAMP wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 70
-
2',3'-cAMP mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 76
-
CDP-choline mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 79
-
CDP-choline mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 83
-
2',3'-cAMP mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 97
-
ADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.6.1.13 0.0001
-
cADP-ribose mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.006
-
CDP-choline mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.008
-
cADP-ribose mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.03
-
ADP-ribose mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.07
-
cADP-ribose mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.1
-
2',3'-cAMP mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.13
-
cADP-ribose mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.13
-
2',3'-cAMP mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.15
-
cADP-ribose mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.29
-
cADP-ribose mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.3
-
CDP-choline mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.4
-
2',3'-cAMP mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.9
-
cADP-ribose mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 0.9
-
cADP-ribose mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.3
-
cADP-ribose mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.5
-
CDP-choline mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.6
-
cADP-ribose mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 1.9
-
2',3'-cAMP mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 2
-
CDP-choline mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 3
-
ADP-ribose mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 3.9
-
2',3'-cAMP mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 4
-
cADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 4
-
CDP-choline mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.13 4
-
2',3'-cAMP mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 4
-
2',3'-cAMP mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 4.1
-
cADP-ribose mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 4.8
-
ADP-ribose mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 6
-
ADP-ribose mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 6
-
2',3'-cAMP mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.13 7
-
2',3'-cAMP mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 9
-
ADP-ribose mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.13 9
-
2',3'-cAMP mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 11
-
ADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 12
-
ADP-ribose mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 14
-
CDP-choline mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 15
-
ADP-ribose mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.13 17
-
CDP-choline mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.13 19
-
2',3'-cAMP mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 21
-
CDP-choline mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 22
-
CDP-choline mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 25
-
2',3'-cAMP wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 28
-
2',3'-cAMP mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 29
-
ADP-ribose mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.13 32
-
2',3'-cAMP mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 34
-
CDP-choline mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.13 35.5
-
cADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 44
-
cADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 52
-
ADP-ribose mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.13 62
-
CDP-choline mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 120
-
ADP-ribose mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.13 150
-
CDP-choline wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 160
-
CDP-choline mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.13 180
-
CDP-choline mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 590
-
ADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.13 650
-
ADP-ribose mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.13 1000
-
ADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.0001
-
cyclic ADP-ribose mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.006
-
CDP-choline mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.03
-
ADP-ribose mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.07
-
cyclic ADP-ribose mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.08
-
cyclic ADP-ribose mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.1
-
2',3'-cAMP mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.13
-
cyclic ADP-ribose mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.13
-
2',3'-cAMP mutant R43A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.15
-
cyclic ADP-ribose mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.29
-
cyclic ADP-ribose mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.3
-
CDP-choline mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.4
-
2',3'-cAMP mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.9
-
cyclic ADP-ribose mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 0.9
-
cyclic ADP-ribose mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.3
-
cyclic ADP-ribose mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.5
-
CDP-choline mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.6
-
cyclic ADP-ribose mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 1.9
-
2',3'-cAMP mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 2
-
CDP-choline mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 3
-
ADP-ribose mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 3.9
-
2',3'-cAMP mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 4
-
cyclic ADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 4
-
CDP-choline mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 4
-
2',3'-cAMP mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 4
-
2',3'-cAMP mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 4.1
-
cyclic ADP-ribose mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 4.8
-
ADP-ribose mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 6
-
ADP-ribose mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 6
-
2',3'-cAMP mutant H111A, pH 7.5, 37°C Homo sapiens
3.6.1.53 7
-
2',3'-cAMP mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 9
-
ADP-ribose mutant F210A, pH 7.5, 37°C Homo sapiens
3.6.1.53 9
-
2',3'-cAMP mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 11
-
ADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 12
-
ADP-ribose mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 14
-
CDP-choline mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 15
-
ADP-ribose mutant N110A, pH 7.5, 37°C Homo sapiens
3.6.1.53 17
-
CDP-choline mutant F37A/L196F, pH 7.5, 37°C Homo sapiens
3.6.1.53 19
-
2',3'-cAMP mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 21
-
CDP-choline mutant F37A/L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 22
-
CDP-choline mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 25
-
2',3'-cAMP wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 28
-
2',3'-cAMP mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 29
-
ADP-ribose mutant H111N, pH 7.5, 37°C Homo sapiens
3.6.1.53 32
-
2',3'-cAMP mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 34
-
CDP-choline mutant F37A, pH 7.5, 37°C Homo sapiens
3.6.1.53 35.5
-
cyclic ADP-ribose mutant F37A/L196F/C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 44
-
cyclic ADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 52
-
ADP-ribose mutant Q27H, pH 7.5, 37°C Homo sapiens
3.6.1.53 62
-
CDP-choline mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 120
-
ADP-ribose mutant L196A, pH 7.5, 37°C Homo sapiens
3.6.1.53 150
-
CDP-choline wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 160
-
CDP-choline mutant C253A, pH 7.5, 37°C Homo sapiens
3.6.1.53 180
-
CDP-choline mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 590
-
ADP-ribose wild-type, pH 7.5, 37°C Homo sapiens
3.6.1.53 650
-
ADP-ribose mutant F37Y, pH 7.5, 37°C Homo sapiens
3.6.1.53 1000
-
ADP-ribose mutant C253A, pH 7.5, 37°C Homo sapiens