EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.6.1.13 | substrate docking on a homology model suggests possible interactions of ADP-ribose with seven residues located, with one exception (Cys253), either within the metallo-dependent phosphatases signature (Gln27, Asn110, His111), or in unique structural regions of the ADPRibase-Mn family: s2s3 (Phe37 and Arg43) and h7h8 (Phe210), around the active site entrance. Residue Phe37 is needed for ADP-ribose preference without catalytic effect. Arg43 is essential for catalysis. Cys253 is hindering for cADPR phosphohydrolase | Homo sapiens |
3.6.1.53 | substrate docking on a homology model of human ADPRibase-Mn suggests possible interactions of ADP-ribose with residue Cys253, within the metallo-dependent phosphatases signature with Gln27, Asn110, His111, or in unique structural regions of the ADPRibase-Mn family, residues Phe37 and Arg43 and Phe210 | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.6.1.13 | C253A | mutant displays a tenfold increased efficiency for cADP-ribose, with no or modest effect on the other substrates | Homo sapiens |
3.6.1.13 | F210A | lowers 40-70fold the catalytic efficiency for ADP-ribose, CDP-choline and 2',3'-cAMP hydrolysis, and 500fold for cADP-ribose | Homo sapiens |
3.6.1.13 | F37A | 19fold increased Km for ADP-ribose, with only a 2-3fold increase of the CDP-choline and 2',3'-cAMP Km values | Homo sapiens |
3.6.1.13 | F37A/L196A | mutation lessens the relative preference for ADP-ribose versus cADP-ribose | Homo sapiens |
3.6.1.13 | F37A/L196F | mutation lessens the relative preference for ADP-ribose versus cADP-ribose | Homo sapiens |
3.6.1.13 | F37A/L196F/C253A | cyclic ADP-ribose is the best substrate for the mutant | Homo sapiens |
3.6.1.13 | F37Y | similar kinetic parameters as the wild type | Homo sapiens |
3.6.1.13 | H111A | marked efficiency decrease with all substrates except 2',3'-cAMP | Homo sapiens |
3.6.1.13 | H111N | marked efficiency decrease with all substrates except 2',3'-cAMP | Homo sapiens |
3.6.1.13 | L196A | mutation causes only a modest 2-5fold decrease of catalytic efficiency with the four substrates tested | Homo sapiens |
3.6.1.13 | N110A | 100-250fold reduction in catalytic efficiency for the hydrolysis of CDP-choline or 2',3'-cAMP | Homo sapiens |
3.6.1.13 | Q27H | mutation reduces 11-13-fold the catalytic efficiency of the hydrolysis of ADP-ribose, CDP-choline or 2',3'-cAMP, and 27fold the hydrolysis of cADP-ribose | Homo sapiens |
3.6.1.13 | R43A | drastic decrease of catalytic efficiency | Homo sapiens |
3.6.1.53 | C253A | 10fold increase of the catalytic efficiency for cyclic ADP-ribose | Homo sapiens |
3.6.1.53 | C253A | Cys253 is hindering for cADPR phosphohydrolase activity, specific tenfold gain of efficiency with cyclic ADP-ribose | Homo sapiens |
3.6.1.53 | F210A | mutation lowers 40-70fold the catalytic efficiency for ADP-ribose, CDP-choline and 2',3'-cAMP hydrolysis, and 500fold for cyclic ADP-ribose | Homo sapiens |
3.6.1.53 | F37A | Phe37 is needed for ADP-ribose preference without catalytic effect | Homo sapiens |
3.6.1.53 | F37A/L196A | modest enhancement of the inhibitory effect over that of the F37A point mutation | Homo sapiens |
3.6.1.53 | F37A/L196F | modest enhancement of the inhibitory effect over that of the F37A point mutation | Homo sapiens |
3.6.1.53 | F37A/L196F/C253A | cyclic ADP-ribose is the best substrate, with a 8fold increase in catalytic efficiency compared to wild-type | Homo sapiens |
3.6.1.53 | F37Y | kinetic parameters similar to wild-type | Homo sapiens |
3.6.1.53 | H111A | marked decrease in efficiency with all substrates except 2',3'-cAMP | Homo sapiens |
3.6.1.53 | H111N | marked decrease in efficiency with all substrates except 2',3'-cAMP | Homo sapiens |
3.6.1.53 | L196A | modest 2-5fold decrease of catalytic efficiency with the substrates tested | Homo sapiens |
3.6.1.53 | N110A | reduction of catalytic efficiency is stronger for the hydrolysis of CDP-choline or 2',3'-cAMP than for the hydrolysis of ADP-ribose or cADPR. The decrease of kcat value is stronger for the hydrolysis of 2',3'-cAMP | Homo sapiens |
3.6.1.53 | Q27H | for ADP-ribose, modest negative effects of similar magnitude in catalysis and in substrate binding. For CDP-choline, the substitution affects only binding. For 2',3'-cAMP, the substitution affects catalysis, not binding | Homo sapiens |
3.6.1.53 | R43A | Arg43 is essential for catalysis, drastic efficiency loss of the mutant | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.13 | 0.06 | - |
ADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.077 | - |
ADP-ribose | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.078 | - |
ADP-ribose | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.094 | - |
ADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.115 | - |
ADP-ribose | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.13 | - |
ADP-ribose | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.14 | - |
ADP-ribose | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.2 | - |
cADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.2 | - |
ADP-ribose | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.29 | - |
ADP-ribose | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.35 | - |
CDP-choline | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.43 | - |
CDP-choline | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.46 | - |
cADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.47 | - |
CDP-choline | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.5 | - |
CDP-choline | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.78 | - |
cADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.97 | - |
CDP-choline | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.05 | - |
2',3'-cAMP | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.15 | - |
ADP-ribose | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.15 | - |
ADP-ribose | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.2 | - |
ADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.25 | - |
CDP-choline | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.25 | - |
2',3'-cAMP | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.5 | - |
CDP-choline | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.6 | - |
ADP-ribose | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.7 | - |
CDP-choline | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.8 | - |
2',3'-cAMP | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.1 | - |
ADP-ribose | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.3 | - |
2',3'-cAMP | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.4 | - |
2',3'-cAMP | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.5 | - |
2',3'-cAMP | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.6 | - |
2',3'-cAMP | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.7 | - |
CDP-choline | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.7 | - |
CDP-choline | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 3.4 | - |
2',3'-cAMP | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4 | - |
CDP-choline | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4.8 | - |
2',3'-cAMP | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 5.1 | - |
2',3'-cAMP | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 5.2 | - |
2',3'-cAMP | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 7.1 | - |
2',3'-cAMP | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 7.5 | - |
CDP-choline | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 7.6 | - |
2',3'-cAMP | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 7.6 | - |
2',3'-cAMP | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 9 | - |
CDP-choline | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 11 | - |
CDP-choline | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.06 | - |
ADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.077 | - |
ADP-ribose | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.078 | - |
ADP-ribose | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.094 | - |
ADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.115 | - |
ADP-ribose | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.13 | - |
ADP-ribose | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.14 | - |
ADP-ribose | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.2 | - |
cyclic ADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.2 | - |
ADP-ribose | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.29 | - |
ADP-ribose | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.35 | - |
CDP-choline | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.43 | - |
CDP-choline | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.46 | - |
cyclic ADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.47 | - |
CDP-choline | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.5 | - |
CDP-choline | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.78 | - |
cyclic ADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.97 | - |
CDP-choline | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.05 | - |
2',3'-cAMP | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.15 | - |
ADP-ribose | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.15 | - |
ADP-ribose | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.2 | - |
ADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.25 | - |
CDP-choline | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.25 | - |
2',3'-cAMP | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.5 | - |
CDP-choline | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.6 | - |
ADP-ribose | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.7 | - |
CDP-choline | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.8 | - |
2',3'-cAMP | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.1 | - |
ADP-ribose | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.3 | - |
2',3'-cAMP | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.4 | - |
2',3'-cAMP | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.5 | - |
2',3'-cAMP | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.6 | - |
2',3'-cAMP | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.7 | - |
CDP-choline | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.7 | - |
CDP-choline | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 3.4 | - |
2',3'-cAMP | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4 | - |
CDP-choline | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4.8 | - |
2',3'-cAMP | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 5.1 | - |
2',3'-cAMP | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 5.2 | - |
2',3'-cAMP | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 7.1 | - |
2',3'-cAMP | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 7.5 | - |
CDP-choline | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 7.6 | - |
2',3'-cAMP | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 7.6 | - |
2',3'-cAMP | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 9 | - |
CDP-choline | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 11 | - |
CDP-choline | mutant F210A, pH 7.5, 37°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.6.1.13 | Homo sapiens | W0NWJ0 | - |
- |
3.6.1.53 | Homo sapiens | W0NWJ0 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.6.1.53 | liver | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.6.1.13 | 2',3'-cAMP + H2O | - |
Homo sapiens | 3'AMP | - |
? | |
3.6.1.13 | ADP-ribose + H2O | - |
Homo sapiens | AMP + D-ribose 5-phosphate | - |
? | |
3.6.1.13 | cADP-ribose + H2O | - |
Homo sapiens | N1-(5-phosphoribosyl)-AMP + phosphate | - |
? | |
3.6.1.13 | CDP-choline + H2O | - |
Homo sapiens | CMP + choline phosphate | - |
? | |
3.6.1.53 | 2',3'-cAMP + H2O | - |
Homo sapiens | ? | - |
? | |
3.6.1.53 | ADP-ribose + H2O | - |
Homo sapiens | AMP + D-ribose 5-phosphate | - |
? | |
3.6.1.53 | CDP-choline + H2O | - |
Homo sapiens | CMP + phosphocholine | - |
? | |
3.6.1.53 | cyclic ADP-ribose + H2O | - |
Homo sapiens | N1-(5-phosphoribosyl)-AMP | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.13 | 0.003 | - |
ADP-ribose | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.025 | - |
CDP-choline | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.11 | - |
2',3'-cAMP | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.47 | - |
ADP-ribose | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.95 | - |
2',3'-cAMP | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2 | 8 | 2',3'-cAMP | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.2 | - |
CDP-choline | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.3 | - |
ADP-ribose | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2.7 | - |
2',3'-cAMP | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 3 | 6 | 2',3'-cAMP | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 3.2 | - |
cADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4.3 | - |
ADP-ribose | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4.3 | - |
2',3'-cAMP | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 5.3 | - |
CDP-choline | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 5.7 | - |
CDP-choline | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 7 | - |
ADP-ribose | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 7.4 | - |
2',3'-cAMP | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 8 | - |
ADP-ribose | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 8.9 | - |
cADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 10 | - |
ADP-ribose | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 13 | - |
ADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 14 | - |
ADP-ribose | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 16 | - |
cADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 16 | - |
ADP-ribose | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 19 | - |
ADP-ribose | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 19 | - |
2',3'-cAMP | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 20 | - |
2',3'-cAMP | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 25 | - |
CDP-choline | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 26 | - |
CDP-choline | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 29 | - |
CDP-choline | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 30 | - |
2',3'-cAMP | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 33 | - |
CDP-choline | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 34 | - |
2',3'-cAMP | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 35 | - |
ADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 37 | - |
CDP-choline | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 39 | - |
CDP-choline | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 50 | - |
CDP-choline | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 50 | - |
CDP-choline | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 50 | - |
ADP-ribose | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 60 | - |
2',3'-cAMP | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 70 | - |
2',3'-cAMP | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 76 | - |
CDP-choline | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 79 | - |
CDP-choline | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 83 | - |
2',3'-cAMP | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 97 | - |
ADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.003 | - |
ADP-ribose | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.025 | - |
CDP-choline | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.11 | - |
2',3'-cAMP | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.47 | - |
ADP-ribose | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.95 | - |
2',3'-cAMP | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2 | 8 | 2',3'-cAMP | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.2 | - |
CDP-choline | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.3 | - |
ADP-ribose | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2.7 | - |
2',3'-cAMP | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 3 | 6 | 2',3'-cAMP | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 3.2 | - |
cyclic ADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4.3 | - |
ADP-ribose | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4.3 | - |
2',3'-cAMP | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 5.3 | - |
CDP-choline | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 5.7 | - |
CDP-choline | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 7 | - |
ADP-ribose | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 7.4 | - |
2',3'-cAMP | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 8 | - |
ADP-ribose | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 8.9 | - |
cyclic ADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 10 | - |
ADP-ribose | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 13 | - |
ADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 14 | - |
ADP-ribose | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 16 | - |
cyclic ADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 16 | - |
ADP-ribose | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 19 | - |
ADP-ribose | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 19 | - |
2',3'-cAMP | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 20 | - |
2',3'-cAMP | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 25 | - |
CDP-choline | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 26 | - |
CDP-choline | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 29 | - |
CDP-choline | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 30 | - |
2',3'-cAMP | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 33 | - |
CDP-choline | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 34 | - |
2',3'-cAMP | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 35 | - |
ADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 37 | - |
CDP-choline | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 39 | - |
CDP-choline | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 50 | - |
CDP-choline | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 50 | - |
CDP-choline | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 50 | - |
ADP-ribose | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 60 | - |
2',3'-cAMP | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 70 | - |
2',3'-cAMP | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 76 | - |
CDP-choline | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 79 | - |
CDP-choline | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 83 | - |
2',3'-cAMP | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 97 | - |
ADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.13 | 0.0001 | - |
cADP-ribose | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.006 | - |
CDP-choline | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.008 | - |
cADP-ribose | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.03 | - |
ADP-ribose | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.07 | - |
cADP-ribose | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.1 | - |
2',3'-cAMP | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.13 | - |
cADP-ribose | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.13 | - |
2',3'-cAMP | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.15 | - |
cADP-ribose | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.29 | - |
cADP-ribose | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.3 | - |
CDP-choline | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.4 | - |
2',3'-cAMP | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.9 | - |
cADP-ribose | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 0.9 | - |
cADP-ribose | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.3 | - |
cADP-ribose | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.5 | - |
CDP-choline | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.6 | - |
cADP-ribose | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1.9 | - |
2',3'-cAMP | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 2 | - |
CDP-choline | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 3 | - |
ADP-ribose | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 3.9 | - |
2',3'-cAMP | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4 | - |
cADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4 | - |
CDP-choline | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4 | - |
2',3'-cAMP | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4 | - |
2',3'-cAMP | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4.1 | - |
cADP-ribose | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 4.8 | - |
ADP-ribose | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 6 | - |
ADP-ribose | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 6 | - |
2',3'-cAMP | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 7 | - |
2',3'-cAMP | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 9 | - |
ADP-ribose | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 9 | - |
2',3'-cAMP | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 11 | - |
ADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 12 | - |
ADP-ribose | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 14 | - |
CDP-choline | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 15 | - |
ADP-ribose | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 17 | - |
CDP-choline | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 19 | - |
2',3'-cAMP | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 21 | - |
CDP-choline | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 22 | - |
CDP-choline | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 25 | - |
2',3'-cAMP | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 28 | - |
2',3'-cAMP | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 29 | - |
ADP-ribose | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 32 | - |
2',3'-cAMP | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 34 | - |
CDP-choline | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 35.5 | - |
cADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 44 | - |
cADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 52 | - |
ADP-ribose | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 62 | - |
CDP-choline | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 120 | - |
ADP-ribose | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 150 | - |
CDP-choline | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 160 | - |
CDP-choline | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 180 | - |
CDP-choline | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 590 | - |
ADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 650 | - |
ADP-ribose | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.13 | 1000 | - |
ADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.0001 | - |
cyclic ADP-ribose | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.006 | - |
CDP-choline | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.03 | - |
ADP-ribose | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.07 | - |
cyclic ADP-ribose | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.08 | - |
cyclic ADP-ribose | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.1 | - |
2',3'-cAMP | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.13 | - |
cyclic ADP-ribose | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.13 | - |
2',3'-cAMP | mutant R43A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.15 | - |
cyclic ADP-ribose | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.29 | - |
cyclic ADP-ribose | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.3 | - |
CDP-choline | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.4 | - |
2',3'-cAMP | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.9 | - |
cyclic ADP-ribose | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 0.9 | - |
cyclic ADP-ribose | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.3 | - |
cyclic ADP-ribose | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.5 | - |
CDP-choline | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.6 | - |
cyclic ADP-ribose | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1.9 | - |
2',3'-cAMP | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 2 | - |
CDP-choline | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 3 | - |
ADP-ribose | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 3.9 | - |
2',3'-cAMP | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4 | - |
cyclic ADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4 | - |
CDP-choline | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4 | - |
2',3'-cAMP | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4 | - |
2',3'-cAMP | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4.1 | - |
cyclic ADP-ribose | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 4.8 | - |
ADP-ribose | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 6 | - |
ADP-ribose | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 6 | - |
2',3'-cAMP | mutant H111A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 7 | - |
2',3'-cAMP | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 9 | - |
ADP-ribose | mutant F210A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 9 | - |
2',3'-cAMP | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 11 | - |
ADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 12 | - |
ADP-ribose | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 14 | - |
CDP-choline | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 15 | - |
ADP-ribose | mutant N110A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 17 | - |
CDP-choline | mutant F37A/L196F, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 19 | - |
2',3'-cAMP | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 21 | - |
CDP-choline | mutant F37A/L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 22 | - |
CDP-choline | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 25 | - |
2',3'-cAMP | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 28 | - |
2',3'-cAMP | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 29 | - |
ADP-ribose | mutant H111N, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 32 | - |
2',3'-cAMP | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 34 | - |
CDP-choline | mutant F37A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 35.5 | - |
cyclic ADP-ribose | mutant F37A/L196F/C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 44 | - |
cyclic ADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 52 | - |
ADP-ribose | mutant Q27H, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 62 | - |
CDP-choline | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 120 | - |
ADP-ribose | mutant L196A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 150 | - |
CDP-choline | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 160 | - |
CDP-choline | mutant C253A, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 180 | - |
CDP-choline | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 590 | - |
ADP-ribose | wild-type, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 650 | - |
ADP-ribose | mutant F37Y, pH 7.5, 37°C | Homo sapiens | |
3.6.1.53 | 1000 | - |
ADP-ribose | mutant C253A, pH 7.5, 37°C | Homo sapiens |