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Literature summary extracted from

  • Kantyka, T.; Pyrc, K.; Gruca, M.; Smagur, J.; Plaza, K.; Guzik, K.; Zeglen, S.; Ochman, M.; Potempa, J.
    Staphylococcus aureus proteases degrade lung surfactant protein a potentially impairing innate immunity of the lung (2013), J. Innate Immun., 5, 251-260.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.29 extracellular
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 Staphylococcus aureus
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-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.29 additional information metalloprotease Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.29 Staphylococcus aureus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.29 proteolytic modification required for enzyme activation Staphylococcus aureus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.29 native enzyme by anion exchange chromatography Staphylococcus aureus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.29 additional information pulmonary surfactant protein-A from human host lung is no substrate for aureolysin from Staphylococcus aureus, but for staphylopain A, EC 3.4.22.48 Staphylococcus aureus ?
-
 ?

General Information

EC Number General Information Comment Organism
3.4.24.29 physiological function the enzyme interacts with the host tissue components in vitro to modulate host defense mechanisms and likely increase bacterial survival, but is not involved in the breakdown of first line of innate immune defense agent, pulmonary surfactant protein-A, of human host lung cells Staphylococcus aureus