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Literature summary extracted from

  • Liu, H.; Stone, S.L.
    Cytoplasmic degradation of the Arabidopsis transcription factor abscisic acid insensitive 5 is mediated by the RING-type E3 ligase KEEP ON GOING (2013), J. Biol. Chem., 288, 20267-20279.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.27 Arabidopsis thaliana Q9FY48
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.27 S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [ABI5]-L-lysine ABI5 i.e. abscisic acid-responsive transcription factor Arabidopsis thaliana [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[ABI5]-L-lysine
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.27 KEEP ON GOING
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 Arabidopsis thaliana
2.3.2.27 KEG
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 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.3.2.27 physiological function RING-type E3 ligase KEG interacts directly with abscisic acid-responsive transcription factor ABI5 via its conserved C3 region. Interactions between KEG and ABI5 are observed in the cytoplasm and trans-Golgi network only when the RING domain of KEG is inactivated or when ABI5 is stabilized via mutations. Deletion of the C-terminal region of ABI5 or substituting lysine 344 for alanine prohibits protein turnover Arabidopsis thaliana