Literature summary extracted from

Nie, J.; Liu, L.; Wu, M.; Xing, G.; He, S.; Yin, Y.; Tian, C.; He, F.; Zhang, L.
HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation (2010), FEBS Lett., 584, 3005-3012.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.2.26	Homo sapiens	Q9HCE7	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.2.26	S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [ING2]-L-lysine	ING2 i.e. candidate tumor suppressor Inhibitor of Growth 2	Homo sapiens	[E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[ING2]-L-lysine	isoform Smurf1 interacts with and targets ING2 for poly-ubiquitination and proteasomal degradation. The ING2 binding domain in Smurf1 was mapped to the catalytic HECT domain. The C-terminal PHD domain of ING2 is required for Smurf1-mediated degradation	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.2.26	Smurf1	-	Homo sapiens

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Release 2026.1 (March 2026)