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Literature summary extracted from

  • Li, Y.; Kong, Y.; Zhou, Z.; Chen, H.; Wang, Z.; Hsieh, Y.C.; Zhao, D.; Zhi, X.; Huang, J.; Zhang, J.; Li, H.; Chen, C.
    The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8 (2013), Cell Death Dis., 4, e935.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.26 medicine isoform HECTD3 is frequently overexpressed in breast carcinomas suggesting that caspase-8 ubiquitination by HECTD3 confers cancer cell survival Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.26 Homo sapiens Q5T447
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.26 HEK-293T cell
-
 Homo sapiens
-
2.3.2.26 MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.26 S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [caspase-8]-L-lysine
-
 Homo sapiens [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[caspase-8]-L-lysine isoform HECTD3 ubiquitinates caspase-8 with K63-linked polyubiquitin chains that do not target caspase-8 for degradation but decrease the caspase-8 activation ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.26 HECTD3
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.2.26 physiological function HECTD3 depletion can sensitize cancer cells to extrinsic apoptotic stimuli. HECTD3 inhibits TNF-related apoptosis-inducing ligand-induced caspase-8 cleavage in an E3 ligase activity-dependent manner. Mutation of the caspase-8 ubiquitination site at K215 abolishes the HECTD3 protection from TNF-related apoptosis-inducing ligand-induced cleavage Homo sapiens