EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.1.1 | drug development | the enzyme might be a good molecular target for lung cancer therapy | Homo sapiens |
2.1.1.1 | pharmacology | the enzyme might be a good molecular target for lung cancer therapy | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.1 | quantitative real-time PCR enzyme expression analysis in non-smalll cell lung cancer samples | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.1 | S-adenosyl-L-methionine + nicotinamide | Homo sapiens | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.1 | A-549 cell | - |
Homo sapiens | - |
2.1.1.1 | additional information | quantitative real-time PCR enzyme expression analysis | Homo sapiens | - |
2.1.1.1 | non-small cell lung cancer cell | the cells show enzyme overexpression compared to both tumor-adjacent and surrounding tissue | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.1.1.1 | additional information | - |
quantitative enzyme activity analysis in 25 non-smalll cell lung cancer samples | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.1 | S-adenosyl-L-methionine + nicotinamide | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.1 | NNMT | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.1 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.1 | 8.6 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.1 | S-adenosyl-L-methionine | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.1 | malfunction | shRNA-mediated gene silencing of NNMT leads to a significntl inhibition of cell proliferation and colony formation ability, downregulation of the enzyme significantly reduces the tumorigenicity of A-549 cells | Homo sapiens |
2.1.1.1 | physiological function | role of nicotinamide N-methyltransferase in non-small cell lung cancer | Homo sapiens |