EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.1.48 | recombinant expression in Escherichia coli strain BL21(DE3) | Mycoplana ramosa |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.5.1.48 | H159A | catalytically inactive mutant | Mycoplana ramosa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.48 | 5-[(3-aminopropyl)amino]pentane-1-thiol | - |
Mycoplana ramosa | |
3.5.1.48 | 5-[(3-aminopropyl)amino]pentylboronic acid | - |
Mycoplana ramosa | |
3.5.1.48 | 6-[(3-aminopropyl)amino]-N-hydroxyhexanamide | - |
Mycoplana ramosa | |
3.5.1.48 | 6-[(3-aminopropyl)amino]hexanoic acid | - |
Mycoplana ramosa | |
3.5.1.48 | 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one | - |
Mycoplana ramosa | |
3.5.1.48 | 7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one | - |
Mycoplana ramosa | |
3.5.1.48 | 7-[(3-aminopropyl)amino]heptan-2-one | - |
Mycoplana ramosa | |
3.5.1.48 | additional information | design, synthesis, and evaluation of N8-acetylspermidine analogues bearing different zinc binding groups as potential inhibitors of the enzyme, overview. Most of the synthesized compounds exhibit modest potency, with IC50 values in the mid-micromolar range, but compounds bearing hydroxamate or trifluoromethylketone zinc binding groups exhibit enhanced inhibitory potency in the mid-nanomolar range. Three compounds exhibit very poor inhibitory potency against th enzyme, 6-[(3-aminopropyl)amino]hexanoic acid, S-{5-[(3-aminopropyl)amino]pentyl} thioacetate, and N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine dihydrochloride | Mycoplana ramosa | |
3.5.1.48 | N',N''-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]-N-hydroxyhexanamide | - |
Mycoplana ramosa | |
3.5.1.48 | N',N''-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]-N-methoxy-N-methylhexanamide | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentan-1-ol | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentane-1-thiol | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]hexanal | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]hexanoic acid | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-ol | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-bromoheptan-2-ol | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-bromoheptan-2-one | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-methoxyheptan-2-ol | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one | - |
Mycoplana ramosa | |
3.5.1.48 | N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]heptan-2-one | - |
Mycoplana ramosa | |
3.5.1.48 | N1,N3-bis(tert-butoxycarbonyl)-N1-(5-bromopentyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | N1,N3-bis(tert-butoxycarbonyl)-N1-(hept-6-enyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | N1,N3-bis(tert-butoxycarbonyl)-N1-(pent-4-enyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(methylthio)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(oxiran-2-yl)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | N1-(hept-6-enyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | N1-(pent-4-enyl)propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine | - |
Mycoplana ramosa | |
3.5.1.48 | S-{5-[(3-aminopropyl)amino]pentyl} thioacetate | - |
Mycoplana ramosa | |
3.5.1.48 | S-{7-[(3-aminopropyl)amino]-2-oxoheptyl} ethanethioate | - |
Mycoplana ramosa | |
3.5.1.48 | S-{N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentyl} thioacetate | - |
Mycoplana ramosa | |
3.5.1.48 | S-{N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-2-oxoheptyl}thioacetate | - |
Mycoplana ramosa |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.48 | Zn2+ | dependent on | Mycoplana ramosa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.48 | additional information | Mycoplana ramosa | the bacterial enzyme from Mycoplana ramosa has broader substrate specificity in comparison with mammalian enzyme. Its substrates include both small and large acetylpolyamines such as acetylputrescine, acetylcadaverine, N1- and N8-acetylspermidine, and N1-acetylspermine | ? | - |
? | |
3.5.1.48 | N1-acetylspermidine + H2O | Mycoplana ramosa | - |
acetate + spermidine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.48 | Mycoplana ramosa | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.48 | acetylcadaverine + H2O | - |
Mycoplana ramosa | acetate + cadaverine | - |
? | |
3.5.1.48 | acetylputrescine + H2O | - |
Mycoplana ramosa | acetate + putrescine | - |
? | |
3.5.1.48 | additional information | the bacterial enzyme from Mycoplana ramosa has broader substrate specificity in comparison with mammalian enzyme. Its substrates include both small and large acetylpolyamines such as acetylputrescine, acetylcadaverine, N1- and N8-acetylspermidine, and N1-acetylspermine | Mycoplana ramosa | ? | - |
? | |
3.5.1.48 | additional information | usage of the commercially available Fluor-de-Lys deacetylase fluorogenic substrate fir enzyme activity assays | Mycoplana ramosa | ? | - |
? | |
3.5.1.48 | N1-acetylspermidine + H2O | - |
Mycoplana ramosa | acetate + spermidine | - |
? | |
3.5.1.48 | N1-acetylspermine + H2O | - |
Mycoplana ramosa | acetate + spermine | - |
? | |
3.5.1.48 | N8-acetylspermidine + H2O | - |
Mycoplana ramosa | acetate + spermidine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.5.1.48 | dimer | - |
Mycoplana ramosa |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.1.48 | acetylpolyamine amidohydrolase | - |
Mycoplana ramosa |
3.5.1.48 | APAH | - |
Mycoplana ramosa |
3.5.1.48 | N1-acetylspermidine deacetylase | - |
Mycoplana ramosa |
3.5.1.48 | N8-acetylspermidine deacetylase | - |
Mycoplana ramosa |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.5.1.48 | 25 | - |
assay at | Mycoplana ramosa |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.5.1.48 | 8.2 | - |
assay at | Mycoplana ramosa |