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Literature summary extracted from

  • Decroos, C.; Bowman, C.M.; Christianson, D.W.
    Synthesis and evaluation of N8-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase (2013), Bioorg. Med. Chem., 21, 4530-4540.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.48 recombinant expression in Escherichia coli strain BL21(DE3) Mycoplana ramosa

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.48 H159A catalytically inactive mutant Mycoplana ramosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.48 5-[(3-aminopropyl)amino]pentane-1-thiol
-
Mycoplana ramosa
3.5.1.48 5-[(3-aminopropyl)amino]pentylboronic acid
-
Mycoplana ramosa
3.5.1.48 6-[(3-aminopropyl)amino]-N-hydroxyhexanamide
-
Mycoplana ramosa
3.5.1.48 6-[(3-aminopropyl)amino]hexanoic acid
-
Mycoplana ramosa
3.5.1.48 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one
-
Mycoplana ramosa
3.5.1.48 7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one
-
Mycoplana ramosa
3.5.1.48 7-[(3-aminopropyl)amino]heptan-2-one
-
Mycoplana ramosa
3.5.1.48 additional information design, synthesis, and evaluation of N8-acetylspermidine analogues bearing different zinc binding groups as potential inhibitors of the enzyme, overview. Most of the synthesized compounds exhibit modest potency, with IC50 values in the mid-micromolar range, but compounds bearing hydroxamate or trifluoromethylketone zinc binding groups exhibit enhanced inhibitory potency in the mid-nanomolar range. Three compounds exhibit very poor inhibitory potency against th enzyme, 6-[(3-aminopropyl)amino]hexanoic acid, S-{5-[(3-aminopropyl)amino]pentyl} thioacetate, and N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine dihydrochloride Mycoplana ramosa
3.5.1.48 N',N''-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]-N-hydroxyhexanamide
-
Mycoplana ramosa
3.5.1.48 N',N''-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]-N-methoxy-N-methylhexanamide
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentan-1-ol
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentane-1-thiol
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]hexanal
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-6-[(3-aminopropyl)amino]hexanoic acid
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-ol
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-bromoheptan-2-ol
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-bromoheptan-2-one
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-methoxyheptan-2-ol
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one
-
Mycoplana ramosa
3.5.1.48 N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]heptan-2-one
-
Mycoplana ramosa
3.5.1.48 N1,N3-bis(tert-butoxycarbonyl)-N1-(5-bromopentyl)propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 N1,N3-bis(tert-butoxycarbonyl)-N1-(hept-6-enyl)propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 N1,N3-bis(tert-butoxycarbonyl)-N1-(pent-4-enyl)propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentyl]propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(methylthio)pentyl]propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 N1,N3-bis(tert-butoxycarbonyl)-N1-[5-(oxiran-2-yl)pentyl]propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 N1-(hept-6-enyl)propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 N1-(pent-4-enyl)propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 N1-[5-(methylsulfonyl)pentyl]propane-1,3-diamine
-
Mycoplana ramosa
3.5.1.48 S-{5-[(3-aminopropyl)amino]pentyl} thioacetate
-
Mycoplana ramosa
3.5.1.48 S-{7-[(3-aminopropyl)amino]-2-oxoheptyl} ethanethioate
-
Mycoplana ramosa
3.5.1.48 S-{N,N'-bis(tert-butoxycarbonyl)-5-[(3-aminopropyl)amino]pentyl} thioacetate
-
Mycoplana ramosa
3.5.1.48 S-{N,N'-bis(tert-butoxycarbonyl)-7-[(3-aminopropyl)amino]-2-oxoheptyl}thioacetate
-
Mycoplana ramosa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.48 Zn2+ dependent on Mycoplana ramosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.48 additional information Mycoplana ramosa the bacterial enzyme from Mycoplana ramosa has broader substrate specificity in comparison with mammalian enzyme. Its substrates include both small and large acetylpolyamines such as acetylputrescine, acetylcadaverine, N1- and N8-acetylspermidine, and N1-acetylspermine ?
-
?
3.5.1.48 N1-acetylspermidine + H2O Mycoplana ramosa
-
acetate + spermidine
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.48 Mycoplana ramosa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.48 acetylcadaverine + H2O
-
Mycoplana ramosa acetate + cadaverine
-
?
3.5.1.48 acetylputrescine + H2O
-
Mycoplana ramosa acetate + putrescine
-
?
3.5.1.48 additional information the bacterial enzyme from Mycoplana ramosa has broader substrate specificity in comparison with mammalian enzyme. Its substrates include both small and large acetylpolyamines such as acetylputrescine, acetylcadaverine, N1- and N8-acetylspermidine, and N1-acetylspermine Mycoplana ramosa ?
-
?
3.5.1.48 additional information usage of the commercially available Fluor-de-Lys deacetylase fluorogenic substrate fir enzyme activity assays Mycoplana ramosa ?
-
?
3.5.1.48 N1-acetylspermidine + H2O
-
Mycoplana ramosa acetate + spermidine
-
?
3.5.1.48 N1-acetylspermine + H2O
-
Mycoplana ramosa acetate + spermine
-
?
3.5.1.48 N8-acetylspermidine + H2O
-
Mycoplana ramosa acetate + spermidine
-
?

Subunits

EC Number Subunits Comment Organism
3.5.1.48 dimer
-
Mycoplana ramosa

Synonyms

EC Number Synonyms Comment Organism
3.5.1.48 acetylpolyamine amidohydrolase
-
Mycoplana ramosa
3.5.1.48 APAH
-
Mycoplana ramosa
3.5.1.48 N1-acetylspermidine deacetylase
-
Mycoplana ramosa
3.5.1.48 N8-acetylspermidine deacetylase
-
Mycoplana ramosa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.48 25
-
assay at Mycoplana ramosa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.48 8.2
-
assay at Mycoplana ramosa