Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kyuma, T.; Kizaki, H.; Ryuno, H.; Sekimizu, K.; Kaito, C.
    16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus (2015), Biochimie, 119, 166-174.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.182 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA Staphylococcus aureus
-
 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?
2.1.1.182 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA Staphylococcus aureus RN4220
-
 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.182 Staphylococcus aureus
-
-
-
2.1.1.182 Staphylococcus aureus RN4220
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.182 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA
-
 Staphylococcus aureus S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?
2.1.1.182 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA
-
 Staphylococcus aureus RN4220 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.182 KsgA
-
 Staphylococcus aureus
2.1.1.182 RsmA
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.1.1.182 malfunction the enzyme knockout strain is sensitive to oxidative stress and has a lower survival rate in murine macrophage RAW264.7 cells than the parent strain Staphylococcus aureus
2.1.1.182 physiological function the enzyme contributes to maintain ribosome function under oxidative conditions and thus to Staphylococcus aureus virulence Staphylococcus aureus