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Literature summary extracted from
- A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin (2005), Biochem. J., 388, 245-254.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.18.6 | expression in CHO cells | Mus musculus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.18.6 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.6 | 70000 | - |
x * 71800, calculated, x * 70000, SDS-PAGE | Mus musculus |
| 1.14.18.6 | 71800 | - |
x * 71800, calculated, x * 70000, SDS-PAGE | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.6 | Mus musculus | Q5MPP0 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.6 | brain | expression in white matter. Time course of expression in brain closely follows the expression of myelin-specific genes, reaching a maximum at 2-3 weeks of age | Mus musculus | - |
| 1.14.18.6 | kidney | - |
Mus musculus | - |
| 1.14.18.6 | skin | - |
Mus musculus | - |
| 1.14.18.6 | stomach | - |
Mus musculus | - |
| 1.14.18.6 | testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.6 | monohexosylceramide + 2 ferrocytochrome b5 + O2 + 2 H+ | - |
Mus musculus | 2'-hydroxymonohexosylceramide + 2 ferricytochrome b5 + H2O | - |
? |  |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.18.6 | ? | x * 71800, calculated, x * 70000, SDS-PAGE | Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.6 | FA2H | - |
Mus musculus |
| 1.14.18.6 | fatty acid 2-hydroxylase | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.6 | cytochrome b5 | - |
Mus musculus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.18.6 | physiological function | transfection of FA2H cDNA in CHO cells leads to the formation of hexosylceramide containing alpha-hydroxylated fatty acid | Mus musculus |
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Release 2023.1 (January 2023)
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