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Literature summary extracted from
- Purification, reconstitution, and inhibition of cytochrome P-450 sterol DELTA22-desaturase from the pathogenic fungus Candida glabrata (1999), Antimicrob. Agents Chemother., 43, 1725-1728.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.41 | fluconazole | competitive inhibition | Nakaseomyces glabratus |  |
| 1.14.19.41 | itraconazole | - |
Nakaseomyces glabratus | |
| 1.14.19.41 | ketoconazole | - |
Nakaseomyces glabratus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.19.41 | 0.0125 | - |
ergosta-5,7-dienol | at pH 6.8 and 37°C | Nakaseomyces glabratus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.19.41 | microsome | - |
Nakaseomyces glabratus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.41 | 59000 | - |
x * 59000, SDS-PAGE | Nakaseomyces glabratus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.41 | Nakaseomyces glabratus | - |
- |
- |
| 1.14.19.41 | Nakaseomyces glabratus L5DU61 | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.19.41 | amino-octyl Sepharose column chromatography and hydroxyapatite column chromatography | Nakaseomyces glabratus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.41 | ergosta-5,7-dienol + NADPH + H+ + O2 | - |
Nakaseomyces glabratus | ergosterol + NADP+ + 2 H2O | - |
? | |
| 1.14.19.41 | ergosta-5,7-dienol + NADPH + H+ + O2 | - |
Nakaseomyces glabratus L5DU61 | ergosterol + NADP+ + 2 H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.19.41 | ? | x * 59000, SDS-PAGE | Nakaseomyces glabratus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.19.41 | cytochrome P-450 sterol DELTA22-desaturase | - |
Nakaseomyces glabratus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.41 | NADPH | - |
Nakaseomyces glabratus | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.19.41 | 0.0000001 | - |
calculated value, pH and temperature not specified in the publication | Nakaseomyces glabratus | ketoconazole | |
| 1.14.19.41 | 0.0000001 | - |
calculated value, pH and temperature not specified in the publication | Nakaseomyces glabratus | itraconazole | |
| 1.14.19.41 | 0.0000001 | - |
calculated value, pH and temperature not specified in the publication | Nakaseomyces glabratus | fluconazole | |
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