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Literature summary extracted from

  • Abdullah, S.N.; Farmer, E.A.; Spargo, L.; Logan, R.; Gully, N.
    Porphyromonas gingivalis peptidylarginine deiminase substrate specificity (2013), Anaerobe, 23, 102-108.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.15 additional information 1 mM tosyl phenylalanyl chloromethyl ketone and 0.043 mM leupeptin do not inhibit enzyme activity Porphyromonas gingivalis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.3.15 cell surface 90% of enzyme activity is cell surface associated Porphyromonas gingivalis 9986
-
3.5.3.15 cytoplasm 10% of enzyme activity is cytoplasn associated Porphyromonas gingivalis 5737
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Porphyromonas gingivalis
-
-
-
3.5.3.15 Porphyromonas gingivalis W50
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.15 agmatine + H2O 5.4% activity compared to L-arginine Porphyromonas gingivalis ? + NH3
-
 ?
3.5.3.15 fibrin L-arginine + H2O
-
 Porphyromonas gingivalis fibrin L-citrulline + NH3
-
 ?
3.5.3.15 fibrin L-arginine + H2O
-
 Porphyromonas gingivalis W50 fibrin L-citrulline + NH3
-
 ?
3.5.3.15 Gly-Gly-L-Arg + H2O 88% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis Gly-Gly-L-Cit + NH3
-
 ?
3.5.3.15 Gly-Gly-L-Arg + H2O 88% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis W50 Gly-Gly-L-Cit + NH3
-
 ?
3.5.3.15 Gly-L-Arg + H2O 130% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis Gly-L-Cit + NH3
-
 ?
3.5.3.15 Gly-L-Arg + H2O 130% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis W50 Gly-L-Cit + NH3
-
 ?
3.5.3.15 human vimentin L-arginine + H2O
-
 Porphyromonas gingivalis human vimentin L-citrulline + NH3
-
 ?
3.5.3.15 L-Arg-Gly + H2O 75% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-Cit-Gly + NH3
-
 ?
3.5.3.15 L-Arg-Gly-Gly + H2O 66% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-Cit-Gly-Gly + NH3
-
 ?
3.5.3.15 L-arginine + H2O 28% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-citrulline + NH3
-
 ?
3.5.3.15 L-arginine + H2O 28% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis W50 L-citrulline + NH3
-
 ?
3.5.3.15 L-canavanine + H2O 0.3% activity compared to L-arginine Porphyromonas gingivalis ? + NH3
-
 ?
3.5.3.15 L-homoarginine + H2O 0.3% activity compared to L-arginine Porphyromonas gingivalis ? + NH3
-
 ?
3.5.3.15 L-Leu-Trp-Met-Arg + H2O 45% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-Leu-Trp-Met-Cit + NH3
-
 ?
3.5.3.15 L-Met-Arg-Phe + H2O the substrate shows fastest rate of citrullination with 158% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-Met-Cit-Phe + NH3
-
 ?
3.5.3.15 L-octopine + H2O 16.7% activity compared to L-arginine Porphyromonas gingivalis ? + NH3
-
 ?
3.5.3.15 Nalpha-benzoyl-L-arginine ethyl ester + H2O 100% activity Porphyromonas gingivalis Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
 ?
3.5.3.15 Nalpha-benzoyl-L-arginine ethyl ester + H2O 100% activity Porphyromonas gingivalis W50 Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
 ?
3.5.3.15 yeast enolase L-arginine + H2O
-
 Porphyromonas gingivalis yeast enolase L-citrulline + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.15 PAD
-
 Porphyromonas gingivalis
3.5.3.15 peptidylarginine deiminase
-
 Porphyromonas gingivalis

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.3.15 60
-
 enzyme activity decreases by 13% following exposure of cells to 60°C for 10 min Porphyromonas gingivalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.3.15 7.5 8
-
 Porphyromonas gingivalis

General Information

EC Number General Information Comment Organism
3.5.3.15 physiological function enzyme's presence in inflamed tissue may promote autoimmune reactions by creation of altered host epitopes Porphyromonas gingivalis