EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.1.92 | vanin-1 is highly expressed in liver and is under transcriptional control of PPAR-alpha and nutritional statu | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.92 | (R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-4-phenylbutyl)butanamide | i.e. RR6, design, synthesis, and characterization of a novel pantetheine analogue, RR6, that acts as a selective, reversible, and competitive vanin inhibitor at nanomolar concentration. Oral administration of RR6 in rats completely inhibits plasma vanin activity and caused alterations of plasma lipid concentrations upon fasting | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.92 | (R)-pantetheine + H2O | Rattus norvegicus | - |
(R)-pantothenate + 2-aminoethanethiol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.92 | Rattus norvegicus | Q4KLZ0 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.1.92 | liver | vanin-1 is highly expressed in liver | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.92 | (R)-pantetheine + H2O | - |
Rattus norvegicus | (R)-pantothenate + 2-aminoethanethiol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.1.92 | vanin-1 | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.5.1.92 | physiological function | vanins are enzymes with pantetheinase activity and are presumed to play a role in the recycling of pantothenic acid (vitamin B5) from pantetheine. Pantothenic acid is an essential nutrient required to synthesize coenzyme A, a cofactor involved in many biological processes such as fatty acid synthesis and oxidation of pyruvate to fuel the citric acid cycle. Hydrolysis of pantetheine also liberates cysteamine, a known antioxidant | Rattus norvegicus |