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Literature summary extracted from

  • Jamin, Y.; Eykyn, T.R.; Poon, E.; Springer, C.J.; Robinson, S.P.
    Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance (2014), Mol. Imaging Biol., 16, 152-157.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.17.11 medicine glutamate chemical exchange saturation transfer magnetic resonance imaging GluCEST-MRI is an attractive method for metabolic imaging of glutamate. The change in glutamate concentration measured with GluCEST MRI could provide a noninvasive biomarker of carboxypeptidase G2 activity, in addition to acting as a surrogate for prodrug activation and the concentration of activated drug in the tumor Pseudomonas sp.

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.11 Pseudomonas sp. P06621
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.11 commercial preparation
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 Pseudomonas sp.
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.11 3,5-difluorobenzoyl-L-glutamate + H2O
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 Pseudomonas sp. 3,5-difluorobenzoate + L-glutamate chemical exchange saturation transfer magnetic resonance study, i.e. CEST-MR to monitor the release of glutamate. CEST-MR affords the detection of CPG2 activity in vitro and supports the translation of CEST-MRI to assess CPG2-based gene therapy in vivo ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.11 carboxypeptidase G2
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 Pseudomonas sp.