Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Michaelson, L.V.; Lazarus, C.M.; Griffiths, G.; Napier, J.A.; Stobart, A.K.
    Isolation of a DELTA5-fatty acid desaturase gene from Mortierella alpina (1998), J. Biol. Chem., 273, 19055-19059.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.30 expression in the yeast Saccharomyces cerevisiae. The yeast cells acquire functional DELTA5-desaturase activity and are capable of synthesizing arachidonic acid from the substrate di-homo-gamma-linolenic acid Mortierella alpina

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.30 56000
-
x * 56000, SDS-PAGE Mortierella alpina

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.30 an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ Mortierella alpina
-
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
?
1.14.19.30 an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ Mortierella alpina CBS 210.32
-
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.30 Mortierella alpina O74212
-
-
1.14.19.30 Mortierella alpina CBS 210.32 O74212
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.19.30 an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O (1) Mortierella alpina
1.14.19.30 an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O (2) Mortierella alpina

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.30 an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
-
Mortierella alpina a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
?
1.14.19.30 an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ (8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome Mortierella alpina a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate ?
1.14.19.30 an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
-
Mortierella alpina CBS 210.32 a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
?
1.14.19.30 an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ (8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome Mortierella alpina CBS 210.32 a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate ?

Subunits

EC Number Subunits Comment Organism
1.14.19.30 ? x * 56000, SDS-PAGE Mortierella alpina

Synonyms

EC Number Synonyms Comment Organism
1.14.19.30 acyl-lipid 5-desaturase
-
Mortierella alpina
1.14.19.30 D5des
-
Mortierella alpina
1.14.19.30 DELTA5-fatty-acid desaturase
-
Mortierella alpina
1.14.19.30 DES5
-
Mortierella alpina