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Literature summary extracted from

  • Nabe, T.; Kijitani, Y.; Kitagawa, Y.; Sakano, E.; Ueno, T.; Fujii, M.; Nakao, S.; Sakai, M.; Takai, S.
    Involvement of chymase in allergic conjunctivitis of guinea pigs (2013), Exp. Eye Res., 113, 74-79.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.39 medicine chymase is a potential target for pharmacotherapy for allergic conjunctivitis Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.39 ketotifen
-
 Cavia porcellus
3.4.21.39 ONO-WH-236 40 and 80 mg/kg used experimentally, potent and selective inhibition of chymase activity Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.39 Cavia porcellus A7WPL7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.39 mast cell
-
 Cavia porcellus
-
3.4.21.39 ophthalmic lavage fluid
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.39 N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
-
 Cavia porcellus N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.39 0.000016
-
 pH and temperature not specified in the publication Cavia porcellus ONO-WH-236

Expression

EC Number Organism Comment Expression
3.4.21.39 Cavia porcellus chymase activity is increased in ophthalmic lavage fluid immediately after the pollen challenge up

General Information

EC Number General Information Comment Organism
3.4.21.39 physiological function chymase is released from mast cells after antigen challenge, followed by the induction of conjunctivitis symptoms through histamine release from mast cells Cavia porcellus