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Literature summary extracted from

  • Kobayashi, T.; Ogawa, M.; Sanada, T.; Mimuro, H.; Kim, M.; Ashida, H.; Akakura, R.; Yoshida, M.; Kawalec, M.; Reichhart, J.M.; Mizushima, T.; Sasakawa, C.
    The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection (2013), Cell Host Microbe, 13, 570-583.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.57 OspC3 the effector molecule of Shigella flexneri interacts with the caspase-4-p19 subunit and inhibits its activation by preventing caspase-4-p19 and caspase-4-p10 heterodimerization by depositing the conserved OspC3 X1-Y-X2-D-X3 motif at the putative catalytic pocket of caspase-4 Cavia porcellus
3.4.22.57 OspC3 the effector molecule of Shigella flexneri interacts with the caspase-4-p19 subunit and inhibits its activation by preventing caspase-4-p19 and caspase-4-p10 heterodimerization by depositing the conserved OspC3 X1-Y-X2-D-X3 motif at the putative catalytic pocket of caspase-4 Homo sapiens
3.4.22.57 Z-VAD
-
 Cavia porcellus
3.4.22.57 Z-VAD
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.57 LEVD-7-amido-4-trifluoromethylcoumarin + H2O Cavia porcellus
-
 LEVD + 7-amino-4-trifluoromethylcoumarin
-
 ?
3.4.22.57 LEVD-7-amido-4-trifluoromethylcoumarin + H2O Homo sapiens
-
 LEVD + 7-amino-4-trifluoromethylcoumarin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.57 Cavia porcellus
-
-
-
3.4.22.57 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.57 HaCaT cell
-
 Homo sapiens
-
3.4.22.57 HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.57 LEVD-7-amido-4-trifluoromethylcoumarin + H2O
-
 Cavia porcellus LEVD + 7-amino-4-trifluoromethylcoumarin
-
 ?
3.4.22.57 LEVD-7-amido-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens LEVD + 7-amino-4-trifluoromethylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.57 CASP4
-
 Cavia porcellus
3.4.22.57 CASP4
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.22.57 physiological function acute inflammatory cell death in the intestinal tract is mediated by caspase-4 Cavia porcellus
3.4.22.57 physiological function acute inflammatory cell death in the intestinal tract is mediated by caspase-4 Homo sapiens